Table 3 Characteristics of AML patients with a wild type or mutated IDH2

No.of cases

230

24

206

No.of males/females

101/129

11/13

90/116

.504

Age, years

.001 ^†

   Median (range)

44 (13-86)

49.5 (38-80)

43 (13-86)

Hemoglobin, g/dL

.059^†

   Median (range)

7.8 (1.4 - 14.5)

9.25 (4.7-12.6)

7.7 (1.4 - 14.5)

WBC count, × 10 ⁹ /L

.789^†

   Median (range)

27.7 (0.6 - 494.4)

29.73 (0.89-222)

26.4 (0.6 - 494.4)

Platelet, x10 ⁹ /L

.048 ^†

   Median (range)

46 (1.8-965)

59 (11-965)

45 (1.8-852)

Percentage of blasts

.133 ^†

   Median (range)

70.19 (6.69-95.44)

61.79 (32.52-95.03)

71.66 (6.69-95.44)

Patients (%)

Patients (%)

FAB classification

   M0

3

0 (0)

3 (1.5)

   M1

51

1 (4)

50 (24)

   M2

76

11 (46)

65 (31)

   M3

36

6 (25)

30 (15)

   M4

34

6 (25)

28 (14)

   M5

21

0 (0)

20 (10)

   M6

8

0 (0)

8 (4)

   M7

1

0 (0)

1 (0.5)

Patients (%)

Patients (%)

Cytogenetics

   Abnormal

   t(15;17)

36

6 (25)

30 (14.6)

.150

   t(8;21)

20

1 (4.2)

19 (9.2)

.355

   inv(16)

3

0 (0)

3 (1.5)

.717

   trisomy 8

4

1 (4.2)

3 (1.5)

.358

   Other trisomies

7

2^‡ (8.2)

5 (2.4)

.158

   All others including monosomies, deletions or combination of these

22

1 (4.2)

21 (10.2)

.301

   Complex karyotype

8

0 (0)

8 (3.8)

.408

   Normal

126

12 (50)

114 (55.3)

.388