Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients

Table 4 Comparison of additional gene mutations in AML patients with and without IDH1 and IDH2 mutations

Additional gene mutations	*IDH1* ^m n = 20 No.	(%)	*IDH1*^wt n = 210 No.	%	P*	*IDH2*^m n = 24 No.	%	*IDH2*^wt n = 206 No.	%	P*
*NPM1*					<.001					<.001
Wild type	5	26%	140	76%		8	40%	137	75%
Mutated	14	74%	45	24%		12	60%	47	25%
*FLT3-* ITD					.34					.63
Absent	14	82%	108	74%		13	76%	109	75%
Present	3	18%	38	16%		4	24%	37	25%
*FLT3-* TKD					.59					.59
Absent	15	94%	133	91%		15	94%	133	91%
Present	1	6%	33	9%		1	6%	33	9%
*AML1*					.09					.09
Wild type	15	100%	147	86%		17	100%	145	86%
Mutated	0	0%	23	14%		0	0%	23	4%
*NRAS*					.49					.42
Wild type	8	89%	79	81%		9	90%	78	81%
Mutated	1	11%	18	19%		1	10%	18	19%
*PML* -RARA					.43					.56
Wild type	3	38%	12	28%		2	25%	13	30%
Mutated	5	62%	31	72%		6	75%	30	70%

ISSN: 1756-8722