Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients

Table 5 Incidence of IDH mutations in AML patients from various countries

Country	No. *IDH1m*/all cases (%)	No. of *IDH1m*/CN-AML (%)	No. *IDH2m*/all cases (%)	No. of *IDH2m*/CN-AML (%)
ASIA
Taiwan
Chou W et al.(2010) [18]	27/493 (5.5)	20/227 (8.8)	ND	ND
China
Zou Y et al.(2010) [28]	4/68 (5.9)	ND	4/48 (8.3)	ND
Zhang Y et al.(2011) [32]	23/365 (6.3)	6/111 (5.4)	ND	ND
Lin J et al.(2011) [31]	4/110 (3.6)	ND	ND	ND
Thailand
This study	20/230 (8.7)	11/126 (8.7)	24/230 (10.4)	12/126 (9.5)
EUROPE^‡[21, 23–27, 30, 41]	6.0-10.9	9.4-16.0	2.0*-10.9	3.2*-15.2
NORTH AMERICA ^∫	2.2-13.7	4.9-16.0	1.3*-19.2	2.4*-19.2
[5, 15, 19, 20, 22, 29]

*The authors only identified IDH2 R172K but did not include IDH2 R140Q mutation; ^† Pediatric acute myeloid leukemia; ^‡ All studies reported during 2010-2011; ^∫ All studies reported during 2009-2011; ND, not determined

ISSN: 1756-8722