|
Study
|
Median PFS (mo)
|
HR
|
P
|
Median OS (mo)
|
HR
|
P
|
|---|
|
GCN + vs GCN-
|
GCN + vs GCN-
|
|---|
|
Bengala 200925
|
--
|
--
|
NS
|
--
|
--
|
NS
|
|
Campanella 201026
|
--
|
0.54
|
0.03
|
--
|
--
|
--
|
|
Cappuzzo 200823
|
6.6 vs 3.5*
|
--
|
0.02
|
11.3 vs 8.5*
|
--
|
0.8
|
|
Goncalves 200829
|
4.1 vs 3.3
|
--
|
--
|
--
|
--
|
--
|
|
Italiano 200815
|
--
|
--
|
0.70
|
--
|
--
|
0.82
|
|
Khambata-Ford 200730
|
4.8 vs 2.0
|
--
|
--
|
--
|
--
|
--
|
|
Laurent-Puig 200916
|
7.9 vs 6.5
|
--
|
0.280
|
19.7 vs 13.9
|
--
|
0.180
|
|
Mancuso 200832
|
6.2 vs 3.2
|
--
|
0.003
|
--
|
--
|
--
|
|
Perrone 200924
|
6 vs 5
|
--
|
--
|
--
|
--
|
--
|
|
Personeni 200833
|
5.5 vs 4
|
--
|
0.25
|
10 vs 8.3
|
--
|
0.037
|
|
Razis 200834
|
8.7 vs 6.4-6.9*
|
0.82
|
NS
|
--
|
--
|
--
|
|
Sartore-Bianchi 200717
|
--
|
--
|
0.039
|
--
|
--
|
0.015
|
|
Sastre 200935
|
4.9 vs 2.6
|
--
|
0.03
|
11.1
|
--
|
--
|
|
Scartozzi 200936
|
7.7 vs 2.9
|
--
|
0.04
|
16 vs 9.5
|
--
|
0.2
|
|
Tol 201037
|
9.5 vs 10.4
|
--
|
0.19
|
21.9 vs 22.0
|
--
|
0.65
|
- PFS, progression-free survival; mo, month; GCN+, increased gene copy number; GCN-, non-increased gene copy number; HR, hazard ratio; OS, overall survival; --, not available; NS, not significant (without detailed numerical values).
- * The original studies did not specify whether the number was “mean” or “median”.
