From: Effect of autoimmune diseases on incidence and survival in subsequent multiple myeloma
Autoimmune disease(case numbers in the two periods) | 1964-1990 | 1991-2008 | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pyrs | O | SIR | 95%CI | Deaths | HR | 95%CI | Pyrs | O | SIR | 95%CI | Deaths | HR | 95%CI | |
Ankylosing spondylitis (4692/1954) | 39322 | 3 | 1.73 | 0.33-5.12 | 1 | 3.60 | 0.50-25.72 | 73502 | 13 | 2.09 | 1.11-3.59 | 2 | 0.40 | 0.10-1.59 |
Behcet disease (3635/239) | 28513 | 3 | 2.14 | 0.40-6.35 | 3 | 1.38 | 0.45-4.29 | 34669 | 3 | 1.12 | 0.21-3.33 | 0 | ||
Chronic rheumatic heart disease (17015/4012) | 85701 | 13 | 1.16 | 0.62-1.99 | 6 | 1.55 | 0.70-3.46 | 80541 | 10 | 0.73 | 0.35-1.35 | 2 | 0.43 | 0.11-1.73 |
Crohn disease (12733/12944) | 110614 | 3 | 1.01 | 0.19-3.00 | 1 | 1.19 | 0.17 -8.43 | 281650 | 12 | 0.78 | 0.40-1.37 | 6 | 1.22 | 0.55-2.71 |
Graves/hyperthyroidism (26633/15387) | 203693 | 22 | 1.32 | 0.82-2.00 | 8 | 0.61 | 0.31-1.23 | 337411 | 30 | 0.89 | 0.60-1.27 | 15 | 1.17 | 0.71-1.95 |
Hashimoto/hypothyroidism (8375/4785) | 43501 | 8 | 1.88 | 0.80-3.72 | 3 | 1.16 | 0.37-3.59 | 77204 | 7 | 0.79 | 0.31-1.64 | 0 | ||
Immune thrombocytopenic purpura (965/3359) | 8640 | 1 | 4.44 | 0.00-25.4 | 1 | 0.53 | 0.07-3.73 | 355800 | 3 | 1.81 | 0.34-5.37 | 1 | 0.61 | 0.09-4.35 |
Multiple sclerosis (8782/5834) | 67706 | 4 | 1.03 | 0.27-2.67 | 2 | 4.02 | 1.01-16.01 | 117308 | 9 | 0.97 | 0.44-1.86 | 5 | 1.14 | 0.47-2.73 |
Myasthenia gravis (1551/1493) | 10430 | 2 | 2.91 | 0.27-10.7 | 0 | 22218 | 2 | 0.88 | 0.08-3.23 | 2 | 1.92 | 0.48-7.67 | ||
Pernicious anemia (9687/1903) | 32746 | 5 | 0.83 | 0.26-1.96 | 3 | 0.72 | 0.23-2.22 | 34350 | 8 | 1.17 | 0.50-2.32 | 7 | 1.37 | 0.66-2.88 |
Polymyalgia rheumatica (13278/14256) | 72444 | 10 | 1.59 | 0.76-2.94 | 5 | 1.35 | -0.563.24 | 180602 | 33 | 1.12 | 0.77-1.57 | 18 | 0.92 | 0.581-1.46 |
Polymyositis/dermatomyositis (1295/1170) | 8310 | 1 | 1.57 | 0.00-9.00 | 0 | 15731 | 3 | 1.89 | 0.36-5.59 | 3 | 6.44 | 2.08-20.0 | ||
Psoriasis (14068/5709) | 112458 | 11 | 1.51 | 0.75-2.71 | 5 | 0.78 | 0.32-1.88 | 163513 | 12 | 0.74 | 0.38-1.30 | 2 | 0.31 | 0.08-1.24 |
Rheumatic fever (3888/418) | 34274 | 4 | 2.05 | 0.53-5.30 | 2 | 5.06 | 1.26-20.28 | 43114 | 4 | 0.99 | 0.26-2.57 | 3 | 4.43 | 1.43-13.7 |
Rheumatoid arthritis (49139/23170) | 304697 | 35 | 1.02 | 0.71-1.41 | 16 | 0.81 | 0.49-1.32 | 427257 | 46 | 0.80 | 0.58-06 | 25 | 1.19 | 0.80-1.77 |
Sarcoidosis (7856/3715) | 69124 | 9 | 2.17 | 0.98-4.14 | 6 | 1.31 | 0.59-2.93 | 108641 | 10 | 0.95 | 0.45-1.76 | 3 | 0.75 | 0.24-2.32 |
Sjögren syndrome (716/1241) | 3386 | 1 | 3.10 | 0.00-17.7 | 1 | 0.87 | 0.12-6.15 | 13314 | 3 | 1.89 | 0.36-5.60 | 0 | ||
Systemic lupus erythematosus (4717/2907) | 31854 | 4 | 1.93 | 0.50-4.99 | 4 | 15.48 | 5.79-41.42 | 54773 | 7 | 1.60 | 0.64-3.32 | 1 | 0.25 | 0.04-1.80 |
Systemic sclerosis (5795/1374) | 36494 | 10 | 3.60 | 1.71-6.64 | 7 | 0.91 | 0.43-1.93 | 53503 | 9 | 2.02 | 0.92-3.85 | 5 | 1.35 | 0.56-3.25 |
Ulcerative colitis (17071/16422) | 136018 | 5 | 0.95 | 0.30-2.23 | 1 | 0.27 | 0.04-1.95 | 350686 | 33 | 1.45 | 1.00-2.04 | 19 | 1.46 | 0.93-2.29 |
Wegener granulomatosis (14233/1600) | 61898 | 14 | 1.20 | 0.65-2.02 | 3 | 0.32 | 0.10-1.00 | 53848 | 12 | 1.14 | 0.59-2.00 | 10 | 1.22 | 0.66-2.28 |
All (253449/149013)1696388 | 1696388 | 171 | 1.31 | 1.12-1.52 | 78 | 0.88 | 0.70-1.10 | 3081277 | 286 | 1.04 | 0.92-1.16 | 137 | 0.99 | 0.99-1.17 |