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Figure 2 | Journal of Hematology & Oncology

Figure 2

From: The unfolded von Willebrand factor response in bloodstream: the self-association perspective

Figure 2

Model for regulation of plasma vWF multimers self-association under shear stress. Plasma vWF multimers circulated in blood are folded into tangled and condensed coils. In this folded conformation, the intradomain interaction may block the A domain and prevent the bindings of vWF to platelet receptors. Under the high shear stress, globular plasma vWF multimers are stretched to covalently associate with each other. The lateral associations can seek to maximize their exposure in order to augment binding capacity and bond strength for platelet GPIb in multiple vWF A1 domains.

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