Effects of Tan IIA on residual tumor, cell hypoxia and epithelial-mesenchymal transition. (A) PR promoted HIF-1α expression and caused epithelial-mesenchymal transition (EMT; upregulated N-cadherin and vimentin, downregulated E-cadherin); Tan IIA reversed EMT in vivo. (B) Hypoxia-induced HIF-1α and promotion of EMT; Tan IIA had no effect on these parameters in vitro. (C), (D) Tan IIA diminished the enlarged Pimonidazole area of residual tumor after PR (50×). *Compared with Sham group, **compared with PR + NS group; p<0.001. (E) Tan IIA upregulated E-cadherin in tumor cells (200×).