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Table 2 miRNAs that influence PCa progression

From: Recent updates on the role of microRNAs in prostate cancer

miRNA

Role in PCa

Function

Study

miR-15a and miR-16

Tumor suppressors

Inhibit cell proliferation, invasion and angiogenesis through regulation of multiple targets

Aqeilan 2010 [25], Musumeci 2011[72]

miR-21

Onco-miRNA

Increases tumor growth, invasion and metastasis

Si 2007 [79], Selciklu 2009 [80], Li 2009 [81], Ribas 2009 [82]

miR-125b

Onco-miRNA

Increases cell proliferation and inhibits apoptosis

Lee 2005 [84], Shi 2007 [26], Vere White 2009 [85]

miR-143

Tumor suppressor

Inhibits cell proliferation and migration by regulating KRAS, MAPK pathways and cell cycle. Also inhibits metastasis

Clape 2009 [67], Xu 2011 [4], Friedman 2009 [73]

miR-145

Tumor suppressor

Inhibits migration, invasion and metastasis

Friedman 2009 [73]

miR-200 s

Tumor suppressor

Inhibit cell migration and invasion by reversing EMT

Kong 2009 and 2010 [69, 70]

miR-221

Onco-miRNA

Stimulates cell growth and influences cell cycle progression

Zheng 2011 [78], Galardi 2007 [77], Sun 2009 [76], Pang 2010 [23].

miR-222

Onco-miRNA

Increased cell cycle progression

Galardi 2007 [77], Sun 2009 [76], Pang 2010 [23].

miR-488

Tumor suppressor

Inhibits Androgen Receptor-mediated cell growth

Sikand 2010 [75]