From: Recent updates on the role of microRNAs in prostate cancer
miRNA | Role in PCa | Function | Study |
---|---|---|---|
miR-15a and miR-16 | Tumor suppressors | Inhibit cell proliferation, invasion and angiogenesis through regulation of multiple targets | |
miR-21 | Onco-miRNA | Increases tumor growth, invasion and metastasis | Si 2007 [79], Selciklu 2009 [80], Li 2009 [81], Ribas 2009 [82] |
miR-125b | Onco-miRNA | Increases cell proliferation and inhibits apoptosis | |
miR-143 | Tumor suppressor | Inhibits cell proliferation and migration by regulating KRAS, MAPK pathways and cell cycle. Also inhibits metastasis | |
miR-145 | Tumor suppressor | Inhibits migration, invasion and metastasis | Friedman 2009 [73] |
miR-200 s | Tumor suppressor | Inhibit cell migration and invasion by reversing EMT | |
miR-221 | Onco-miRNA | Stimulates cell growth and influences cell cycle progression | Zheng 2011 [78], Galardi 2007 [77], Sun 2009 [76], Pang 2010 [23]. |
miR-222 | Onco-miRNA | Increased cell cycle progression | |
miR-488 | Tumor suppressor | Inhibits Androgen Receptor-mediated cell growth | Sikand 2010 [75] |