Figure 1
From: Different mutations of the human c-mpl gene indicate distinct haematopoietic diseases
A schematic summary of the mechanism that different mutations of human c-mpl gene (MPL) bring about distinct biological effects. Type 1 mutation: MPL mutations found in CAMT. Type 2 mutation: MPL-S505N、K39N、 P106L mutations found in HT. Type 3 mutation: MPL-W515L and W515K mutations found in MPNs, RARS-t and AML. Type 4 mutation: MPL-W515A, W515R, W515-P518delinsKT, Y591D, A519T, L510P, A506T, T487A, Y252H, S204P, S204F, IVS 11/12 and IVS 10/11.