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Figure 5 | Journal of Hematology & Oncology

Figure 5

From: Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice

Figure 5

Reduced repopulating capacity of Pim TKO BM cells in competitive transplants. 5×105 total BM cells from male Pim TKO mice or WT controls, along with 2×105 female competitor BM cells, were transplanted into irradiated female recipients. (A) Reduced engraftment capacity of Pim TKO BM cells. Male donor engraftment in peripheral blood at 12 weeks post transplant was estimated (**p < 0.01). (B) Reduced engraftment in all three main cell subsets with Pim TKO BM cells. Gr-1+ granulocytes, CD3e+ T cells and B220+ B cells were sorted from pooled peripheral blood samples. Genomic DNAs from each population were isolated and the male donor cell contribution in these cell subsets was determined.

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