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Table 3 Identified pathologic stressors that induce mtROS in endothelial cells (ECs)

From: Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

Cell type Treatment Dose Time PMID
Bovine aortic ECs Oxidized LDL 200 μg/ml 30 min 15805232
Bovine aortic ECs Electrophilic lipids 4 μM 4 h 16387790
Human umbilical vein ECs LysoPC 5 μmol/L 60 min 16651638
Porcine aortic ECs Glycated LDL 100 μg/ml 2 h 20036735
Bovine aortic ECs Glucose 30 mM 2 h 10783895
Human aorta ECs Glucose 25 mM 7 d 12600878
bEnd3 microvascular ECs Glucose 40 mM 7 d 21808008
Human umbilical vein ECs Low Glucose ≤ 80 mg/dL 5 min 22207730
Bovine aortic ECs Angiotensin II 200 nmol/L 4 h 18096818
Human aortic ECs Angiotensin II 200 nmol/L 4 h 20448215
Human aortic ECs Homocysteine 150 μM 24 h 21672628
Human umbilical vein ECs Hypoxia 14 mmHg 30 min 11950692
Human umbilical vein ECs Hypoxia 0 mmHg 24 h 12165534
Porcine aortic ECs Hypoxia 0 mmHg 1 h 12690038
Murine pulmonary ECs Thrombin 1 mU/mL 100 s 17724077
Human umbilical vein ECs PAR1-AP 50 μmol/L 1 h 18983479
Human umbilical vein ECs TNF-α 1 ng/mL 1 h 11415943
Murine pulmonary ECs TNF-α 1 ng/mL 10 min 21519143
Bovine aortic ECs Leptin 10 ng/mL 45 min 11342529
Human coronary artery ECs Resistin 40/80 ng/mL 24 h 20435848
Human umbilical vein ECs VEGF 50 ng/mL 5 min 21653897
  1. PMID: PubMed ID.