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Table 3 Identified pathologic stressors that induce mtROS in endothelial cells (ECs)

From: Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

Cell type

Treatment

Dose

Time

PMID

Bovine aortic ECs

Oxidized LDL

200 μg/ml

30 min

15805232

Bovine aortic ECs

Electrophilic lipids

4 μM

4 h

16387790

Human umbilical vein ECs

LysoPC

5 μmol/L

60 min

16651638

Porcine aortic ECs

Glycated LDL

100 μg/ml

2 h

20036735

Bovine aortic ECs

Glucose

30 mM

2 h

10783895

Human aorta ECs

Glucose

25 mM

7 d

12600878

bEnd3 microvascular ECs

Glucose

40 mM

7 d

21808008

Human umbilical vein ECs

Low Glucose

≤ 80 mg/dL

5 min

22207730

Bovine aortic ECs

Angiotensin II

200 nmol/L

4 h

18096818

Human aortic ECs

Angiotensin II

200 nmol/L

4 h

20448215

Human aortic ECs

Homocysteine

150 μM

24 h

21672628

Human umbilical vein ECs

Hypoxia

14 mmHg

30 min

11950692

Human umbilical vein ECs

Hypoxia

0 mmHg

24 h

12165534

Porcine aortic ECs

Hypoxia

0 mmHg

1 h

12690038

Murine pulmonary ECs

Thrombin

1 mU/mL

100 s

17724077

Human umbilical vein ECs

PAR1-AP

50 μmol/L

1 h

18983479

Human umbilical vein ECs

TNF-α

1 ng/mL

1 h

11415943

Murine pulmonary ECs

TNF-α

1 ng/mL

10 min

21519143

Bovine aortic ECs

Leptin

10 ng/mL

45 min

11342529

Human coronary artery ECs

Resistin

40/80 ng/mL

24 h

20435848

Human umbilical vein ECs

VEGF

50 ng/mL

5 min

21653897

  1. PMID: PubMed ID.