Comparative efficacy of tandem autologous versus autologous followed by allogeneic hematopoietic cell transplantation in patients with newly diagnosed multiple myeloma: a systematic review and meta-analysis of randomized controlled trials

Table 2 Methodological quality of biologically randomized studies in tandem autologous versus autologous-allogeneic hematopoietic cell transplantation for patients with multiple myeloma

	Risk of bias								Risk of random error
Study	Groups balanced on prognostic factors	All consecutive patients included	At least 1:2 ratio of auto-allo HCT versus auto-auto HCT	Description of withdrawals/ dropouts	Blinding of any study personnel	Same reference time used for both arms	Report ITT analysis of benefits	Report per protocol analysis of harms	A priori expected difference stated	α & β error pre-specified	Sample size calculations performed
Björkstrand, 2011	yes	unclear	yes	no	no	yes	yes	yes	no	no	no
Giaccone, 2011	yes	unclear	yes	yes	no	yes	yes	yes	no	no	no
Knop, 2009	unclear	unclear	yes	no	no	unclear	unclear	unclear	no	no	no
Krishnan & Pasquini, 2011	yes	unclear	yes	yes	no	yes	yes	no	yes	yes	yes
Rosiñol, 2008	yes	unclear	no	yes	no	yes	no	yes	no	no	no

ISSN: 1756-8722