Table 4 Sensitivity analyses by response criteria and significant elements of quality
Subgroup | Outcome | Studies | Patients | HR or RR | 95% CI | Heterogeneity | Test of Interaction |
|---|---|---|---|---|---|---|---|
Tool used to capture response | |||||||
EBMT criteria | ORR (per-protocol) | 1 | 195 | 0.96 | (0.96–1.04) | NA | 0.26 |
Non-EBMT/IUR criteria | 1 | 104 | 0.94 | (0.82–1.08) | NA | ||
Criteria not reported | 1 | 199 | 1.06 | (0.95–1.18) | NA | ||
EBMT criteria | CR (per-protocol) | 2 | 305 | 2.05 | (0.71–5.98) | 85% | 0.12 |
IUR criteria | 1 | 522 | 1.29 | (1.08–1.54) | NA | ||
Non-EBMT/IUR criteria | 1 | 104 | 2.11 | (1.23–3.63) | NA | ||
Criteria not reported | 1 | 199 | 1.86 | (1.29–1.54) | NA | ||
At least 1:2 ratio of auto-allo HCT versus auto-auto HCT | |||||||
Yes | OS (per-protocol) | 1 | 104 | 0.55 | (0.32–0.94) | NA | 0.04 |
No |  | 1 | 110 | 1.51 | (0.70–3.27) | NA |  |
Description of withdrawals/dropouts | |||||||
Yes | OS (ITT) | 2 | 872 | 0.81 | (0.34–1.92) | 92% | 0.93 |
No | 1 | 357 | 0.77 | (0.55–1.08) | NA | ||
Report calculation of sample size | |||||||
Yes | OS (ITT) | 1 | 710 | 1.24 | (0.94–1.64) | NA | 0.007 |
No | 2 | 519 | 0.64 | (0.43–0.95) | 58% | ||