Table 1 Calculated IC 50 values for AML cell lines and primary blasts at 48 h
Cell line | FLT3 status | IC50(95% Confidence intervals) |
|---|---|---|
MV4-11 | FLT3-ITD | 2.65 nM (1.49 to 4.72) |
THP-1 | FLT3-wt | 3.81 nM (2.46 to 5.09) |
Primary blasts | Â | Â |
Pat #1 | FLT3-wt | 16.9 nM (13.6 to 21.1) |
Pat #2 | FLT3-wt | 6.61 nM (5.67 to 7.70) |
Pat #3 | FLT3-ITD | 3.65 nM (2.21 to 6.04) |
Pat #4 | FLT3-ITD | 4.89 nM (3.90 to 6.12) |
Pat #5 | FLT3-ITD | 6.41 nM (4.07 to 10.1) |