Table 1 Small molecules used for targeting p53 in various hematoloigcal malignancies
From: Targeting p53 by small molecules in hematological malignancies
Hematological malignancy | Small molecule | Potential target |
|---|---|---|
Leukemia | Â | Â |
ALL | Nutlin | MDM232-34 |
| Â | RITA | p5382 |
| Â | JNJ-26854165 | p53, E2F199 |
AML | *Nutlin | MDM235,38,42,43,46 |
| Â | MI-219 | MDM248 |
| Â | RITA | p538 |
| Â | *PRIMA-1 | p538,82,88,93 |
| Â | JNJ-26854165 | p53, E2F199 |
CLL | Nutlin | MDM254-56,58-60 |
| Â | RITA | p538 |
| Â | PRIMA-1 | p538,92 |
CML | Nutlin | MDM261,62 |
| Â | MI-219 | MDM261 |
Lymphoma | Â | Â |
HL | Nutlin | MDM267,68 |
MCL | Nutlin | MDM269-72 |
Birkitt’s lymphoma | Nutlin | MDM276 |
B Cell lymphoma | MI-219 | MDM274 |
Follicular lymphoma | MI-319 | MDM278 |
Myeloma | Nutlin | MDM263-65 |
| Â | RITA | p5384, JNK87 |
| Â | PRIMA-1Met | p53, p7394 |
| Â | MIRA-1 | p5396 |
| Â | Halofuginone | p5397 |