Table 1 Small molecules used for targeting p53 in various hematoloigcal malignancies
From: Targeting p53 by small molecules in hematological malignancies
| Hematological malignancy | Small molecule | Potential target |
|---|---|---|
| Leukemia | ||
| ALL | Nutlin | MDM232-34 |
| RITA | p5382 | |
| JNJ-26854165 | p53, E2F199 | |
| AML | *Nutlin | MDM235,38,42,43,46 |
| MI-219 | MDM248 | |
| RITA | p538 | |
| *PRIMA-1 | p538,82,88,93 | |
| JNJ-26854165 | p53, E2F199 | |
| CLL | Nutlin | MDM254-56,58-60 |
| RITA | p538 | |
| PRIMA-1 | p538,92 | |
| CML | Nutlin | MDM261,62 |
| MI-219 | MDM261 | |
| Lymphoma | ||
| HL | Nutlin | MDM267,68 |
| MCL | Nutlin | MDM269-72 |
| Birkitt’s lymphoma | Nutlin | MDM276 |
| B Cell lymphoma | MI-219 | MDM274 |
| Follicular lymphoma | MI-319 | MDM278 |
| Myeloma | Nutlin | MDM263-65 |
| RITA | p5384, JNK87 | |
| PRIMA-1Met | p53, p7394 | |
| MIRA-1 | p5396 | |
| Halofuginone | p5397 |