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Table 1 Small molecules used for targeting p53 in various hematoloigcal malignancies

From: Targeting p53 by small molecules in hematological malignancies

Hematological malignancy Small molecule Potential target
Leukemia   
ALL Nutlin MDM232-34
  RITA p5382
  JNJ-26854165 p53, E2F199
AML *Nutlin MDM235,38,42,43,46
  MI-219 MDM248
  RITA p538
  *PRIMA-1 p538,82,88,93
  JNJ-26854165 p53, E2F199
CLL Nutlin MDM254-56,58-60
  RITA p538
  PRIMA-1 p538,92
CML Nutlin MDM261,62
  MI-219 MDM261
Lymphoma   
HL Nutlin MDM267,68
MCL Nutlin MDM269-72
Birkitt’s lymphoma Nutlin MDM276
B Cell lymphoma MI-219 MDM274
Follicular lymphoma MI-319 MDM278
Myeloma Nutlin MDM263-65
  RITA p5384, JNK87
  PRIMA-1Met p53, p7394
  MIRA-1 p5396
  Halofuginone p5397
  1. *in phase I/II clinical trials.91,101.