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Figure 2 | Journal of Hematology & Oncology

Figure 2

From: Inosine Triphosphate Pyrophosphohydrolase (ITPA) polymorphic sequence variants in adult hematological malignancy patients and possible association with mitochondrial DNA defects

Figure 2

Total homoplasmic and heteroplasmic mutations in mtDNA of AHM patients. 13 AHM patients carrying the ITPA 94A variant allele (i.e. ITPA+/−) comprised MDS (closed circles) n=8, CLL (open triangles) n=4, AML (open circles) n=1. These were compared with 4 patients homozygous for the ITPA 94C wildtype allele (i.e. ITPA+/+), comprising MDS n=2, CLL n=1 and AML n=1. Mutations were identified against the MitoChip standard mtDNA reference sequence (rCRS) and those belonging to the assigned mtDNA haplogroup of each patient excluded. The results are shown as means ± SEM (p < 0.009, Mann–Whitney two-tailed test).

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