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Figure 2 | Journal of Hematology & Oncology

Figure 2

From: Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia

Figure 2

Characterization of identified PU.1 binding regions. (A) Pie diagram showing distribution of PU.1 binding regions located in the proximal promoter (within 2 kb 5 and 1kb 3 to the TSS), gene body (+1kb of TSS to transcription end site, TES), upstream enhancer (between at most -50 kb and -2 kb from TSS), downstream enhancer (from TES to at most 50 kb downstream), or distal intergenic regions (more than 50 kb to TSS and TES). (B) Evolutionary conservation analysis of each genomic type of PU.1 binding regions used multiple alignments of 27 vertebrate genomes with human. All the regions are aligned at peak summits in a 5-to-3 manner. (C) Correlation of the binding sites of PU.1, STAT1, ER, FOXA1, RNAPII, CTCF, GATA1 and GATA2 with each chromosome, ranked according to total gene number and total nucleotide number. (D) Representative PU.1 target genes identified through ChIP-seq analysis. (Arrows) ChIP-seq peak locations relative to the transcription start site of the respective PU.1 target gene (kb).

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