Figure 3

Schematic depicting the transition between telomere maintenance mechanisms in CML samples. (A) 3 out of 24 CML samples showed overlapping expression for both ECTR circles and telomerase activities at the transition state (between dashed vertical lines). (B) 4 out of 24 CML samples had neither detectable ECTR nor telomerase activity during the transition state (between dashed vertical lines). N: number of cases observed; +/+: double positive for telomerase and possible ALT mechanisms; -/-: double negative for telomerase and possible ALT mechanisms.