Table 3 Specific adverse events*,†
Variable | Grade | n pts., (%) | n total events |
|---|---|---|---|
Hematologic toxicity # | G3–4 | 69 (44.5) | 148 |
Thrombopenia | G3–4 | 38 (24.5) | 87 |
Neutropenia | G3–4 | 49 (31.6) | 99 |
Anemia | G3–4 | 33 (21.3) | 80 |
Bleeding events | – | 14 (9.0) | 31 |
Febrile neutropenia | – | 28 (18.1) | 46 |
Infectious complications | Total | 98 (63.2) | 256 |
G1 | 14 (9.0) | 85 | |
G2 | 39 (25.2) | 107 | |
G3 | 16 (10.3) | 26 | |
G4 | 29 (18.7) | 38 | |
Non-hematologic toxicity | |||
Liver | G1-2 | 1 (0.6) | 1 |
G3-4 | 0 (0.0) | 0 | |
Kidney | G1-2 | 5 (3.2) | 5 |
G3-4 | 0 (0.0) | 0 | |
Heart | G1-2 | 3 (1.9) | 5 |
G3-4 | 13 (8.4) | 15 | |
Blood pressure | G1-2 | 2 (1.3) | 2 |
G3-4 | 1 (0.6) | 1 | |
Metabolic | G1-2 | 1 (0.6) | 1 |
G3-4 | 0(0.0) | 0 | |
Thromboembolic | G1-2 | 9 (5.8) | 10 |
G3-4 | 1 (0.6) | 1 | |
Neurologic | G1-2 | 11 (7.1) | 18 |
G3-4 | 1 (0.6) | 1 | |
Nausea | G1-2 | 16 (10.3) | 24 |
G3-4 | 0 (0.0) | 0 | |
Vomiting | G1-2 | 4 (2.6) | 5 |
G3-4 | 0 (0.0) | 0 | |
Constipation | G1-2 | 3 (1.9) | 5 |
G3-4 | 0 (0.0) | 0 | |
Diarrhea | G1-2 | 17 (11.0) | 25 |
G3-4 | 0 (0.0) | 0 | |
GIT-others | G1-2 | 11 (7.1) | 11 |
G3-4 | 0 (0.0) | 0 | |
Injection site reaction | G1-2 | 32 (20.6) | 48 |
G3-4 | 0 (0.0) | 0 | |
Fatigue | Total | 65 (41.9) | 99 |
Relieved by rest | 24 (15.5) | 50 | |
Not relieved by rest | 25 (16.1) | 32 | |
Limiting self care | 16 (10.3) | 17 | |
Pain | Total | 46 (29.7) | 78 |
Mild | 25 (16.1) | 52 | |
Moderate | 18 (11.6) | 23 | |
Severe | 3 (1.9) | 3 | |
Surgery | Total | 20 (12.9) | 24 |
Elective | 13 (8.4) | 16 | |
Emergency | 7 (4.5) | 8 | |
Fall | Total | 14 (9.0) | 16 |
With fracture | 8 (5.2) | 9 | |
With hemorrhage | 5 (3.2) | 8 | |
Novel solid tumor | Yes | 3 (1.9) | 3 |