Figure 1

Cytomorphology of bone marrow (BM) aspirates at diagnosis and at remission controls obtained after the first cycle of sequential therapy. Case 1 (left column): (i) Aspirate at primary diagnosis showing 80% BM infiltration with myeloid blasts. The malignant cells show large nuclei, narrow cytoplasm and fine azurophilic granula. (iii) Complete remission (CR1) achieved after one cycle of low-dose cytarabine (LDAC)/sorafenib. Differentiating granulopoiesis and reappearance of megakaryopoiesis as observed after reconstitution of peripheral blood counts. Case 2 (right column): (ii) Predominant expansion of the erythroid lineage with pronounced dysplasia. The non-erythroid cells show 67% of myeloid blasts consistent with the diagnosis of erythroleukemia (FAB M6). (iv) Reduction of cellularity and reconstitution of granulopoiesis following the first cycle of sequential LDAC/sorafenib therapy. Achievement of complete hematologic remission with concomitant reconstitution of peripheral blood counts.