Table 3 Optic toxicity after combined techniques for sinonasal malignancies

Jansen [14]^§

68

66

T₄: 63.2%

2D/3D

66 Gy/33 frx^ǂ

64.4%

LON: 73.8

27.9%; 33.3% patients with orbital invasion experienced severe optic toxicity

22.1%

5 yr LC:

Gy₂^ǂ*

Definitive: 47%

RON: 73.8 Gy₂^ǂ*

Postoperative: 65%

OC: 70 Gy₂^ǂ*

Snyers [15]^§

168

69

T₄: 57.6%

2D/3D

64 Gy/32 frx^ǂ

64%

1 case of unilateral blindness after both optic nerves received a maximum dose of 61 Gy

14% LENT SOMA grade 3–4 opthalmologic toxicity at 5 years (2D 15%, 3D 4%)

2.4% unilateral blindness

Porceddu [16]^§

60

67

T₄: 56.67%

2D/3D

50-70 Gy, 1.8-2 Gy/frx; 60 Gy/30 frx for 3D CRT

62%

ON/OC dose was limited to 54 Gy

n/a

3 due to disease progression

Blanco [17]^§

106

60

T₄: 55.7%

2D/3D

Definitive 61.7 Gy^¶

58.5%

1 IMRT successfully spared optic nerves and chiasm with mean doses of 33.9 Gy & 38.9 Gy to those two structures

Optic neuropathy in 2 pts (1.9%) & optic retinopathy in 1 pt (0.9%); all led to blindness

2.8%

Postoperative 60.9 Gy^¶

Preoperative 55.7 Gy^¶

Mostly 1.8-2 Gy/frx

Hoppe [18]^§

39

20

T4b: 100%

2D/3D: 69%, IMRT 31%

70 Gy/35 frx^ǂ

35.9%

n/a

1 case of Optic neuropathy, 77 Gy to ON

1 due to optic neuropathy 7 years after IMRT

Mendenhall [19]

109

51.6

T4: 32%

2D/3D mostly

Preoperative: 55 Gy^ǂ

5 yr LC: 63%

n/a

n/a

Definitive RT:

Postoperative: 64.8 Gy^ǂ

T1-3: 82%

-Ipsilateral: 25%

T4: 50%

-Bilateral: 1.8%

Definitive: 70 Gy^ǂ

Definitive: 43%

Pre or post operative:

Postoperative: 84%

-Ipsilateral: 7.5%

-Bilateral: 1.9%