PK parametera | Day 1 | Day 7: lenalidomide alone | Day 8: lenalidomide plus low-dose dexamethasone |
---|---|---|---|
(n = 11) | (n = 10) | (n = 10) | |
Tmax (h) | 0.93 (0.50–3.17) | 1.50 (0.50–3.08) | 1.00 (0.50–2.98) |
Cmax (ng/ml) | 574 (28.3) | 478 (19.3) | 494 (19.9) |
AUCt (h•ng/ml) | 2323 (40.1) | 1963 (36.6) | 2093 (41.2) |
AUC∞ (h•ng/ml) | 2403 (41.2) | 2141 (45.4) | 2162 (42.6) |
t1/2 (h) | 3.34 (41.9) | 2.79 (32.6) | 3.08 (46.8) |
CL/F (ml/min) | 173 (41.2) | 195 (45.4) | 193 (42.6) |
RAC (Cmax) | NA | 0.84 (29.2) | NA |
RAC (AUCÏ„) | NA | 0.89 (17.9) | NA |