From: Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology
Procoagulant activity | Inhibition of heparin-dependent thrombin inactivation [15] |
Anticoagulant activity | Inhibition of factor XII [16] and vitamin K dependent coagulation factors [17] |
Generation of activated protein C [18] | |
Regulation of hematopoiesis | |
Survival of hematopoietic and progenitor cells [73] | |
Inhibition of BFU-E, CFU-GM and CD34+ progenitors proliferation [24, 25] | |
Immunoregulatory activity | Stimulation of neutrophil adhesion and secondary granule exocytosis [36, 71, 72, 74] |
Stimulation of monocyte adhesion and activation [64, 75, 76] | |
Induction of monocyte differentiation into macrophage [77] and APC [78] | |
Stimulation of eosinophil adhesion [79] | |
Stimulation of histamine release by basophils [80] | |
Activation of NK cells and IL-8 release [81] | |
Inhibition of T-cell activation and proliferation [82] | |
Anti-angiogenic activity | |
Competition with growth factors (VEGF, bFGF) for glycosaminoglycan (GAGs) binding [47, 48] | |
Prevention of EC entry into S phase and inhibition of DNA synthesis [56] | |
 | Monocyte ROS mediated cytotoxicity for EC [64] |