Table 4 Toxicity profile of CHOP-L regimen
| Â | Toxicity Incidence, No. (%) | ||||
|---|---|---|---|---|---|
Toxicity | Grade 0 | Grade 1 | Grade 2 | Grade3 | Grade 4 |
Hematologic toxicity | Â | Â | Â | Â | Â |
  Leukopenia | 1(2.6%) | 2(5.3%) | 6(15.8%) | 15(39.5%) | 14(36.8%) |
  Neutropenia | 1(2.6%) | 2(5.3%) | 3(7.9%) | 9(23.7%) | 23(60.5%) |
  Anemia | 16(42.1%) | 9(23.7%) | 10(26.3%) | 3(7.9%) | 0 |
  Thrombocytopenia | 29(76.3%) | 5(13.2%) | 4(10.5%) | 0 | 0 |
Digestive tract effect | Â | Â | Â | Â | Â |
  Nausea, vomiting | 7(18.4%) | 5(13.2%) | 9(23.7%) | 13(34.2%) | 4(10.5%) |
Liver dysfunction | Â | Â | Â | Â | Â |
  Increase in ALT/AST | 7(18.4%) | 15(39.5% | 12(31.6%) | 4(10.5%) | 0 |
  Increase in bilirubin | 24(63.2%) | 12(31.6%) | 2(5.3%) | 0 | 0 |
Increase in BUN | 32(84.2%) | 6(15.8%) | 0 | 0 | 0 |
Hypoalbuminemia | 16(42.1%), the minimum value was 27.9Â g/L | ||||
Decrease in FIB | 33(86.8%), the minimum value was 55.2Â mg/dL | ||||
Hypertriglyceridemia | 8(21.1%), the maximum value was 16.04Â mmol/L | ||||
Hypercholesterolemia | 9(23.7%), the maximum value was 11.31Â mmol/L | ||||
Hypocalcemia | 5(13.2%), the minimum value was 1.11Â mmol/L | ||||
Hypoglycemia | 6(15.8%) | ||||
Hyperglycemia | 2(5.3%) | ||||
Changes in EKG | 9(23.7%) | ||||
Lung injury | 5(13.2%), 3 with grade 1, 2 with grade 2 | ||||
Febril neutropenia | 8(21.1%) | ||||
Infection with grade 3 to 4 neutropenia | 4(10.5%) | ||||
Infection without neutropenia | 1(2.6%) | ||||