Skip to main content

Table 5 Comparison of PK parameters between Chinese, Caucasian and Japanese patients

From: A phase I study of ridaforolimus in adult Chinese patients with advanced solid tumors

PK parameters Chinese Caucasian Japanese
Single dose
AUC0-24 (ng.hr/ml)a 1846 (1361, 2503) 992(801, 1230) 1,470 (914, 2,360)
Cmax (ng/ml)a 210 (150, 295) 112(84.6, 148) 187 (115, 304)
Tmax (hr)b 4.03 (2.00, 7.97) 2.79(1.42, 9.78) 4.00 (4.00, 8.00)
t1/2 (hr) 52.9 (40.2, 65.6)c 42.0(17.7)d 55.8 (50.95, 60.65)c
Multiple dose
AUC0-24 (ng.hr/ml) 2014 (1485, 2731) 1882(1630, 2180) 2,120 (1,320, 3,410)
Cmax (ng/ml) 167 (119, 234) 160(136, 188) 188 (116, 306)
Tmax (hr) 4.00 (0.00, 6.00) -- 4.04 (4.00, 8.15)
Accumulation ratioe
AUC0-24 1.3(1.0, 1.6) 1.90(1.63, 2.21) 1.44 (1.05, 1.99)
Cmax 1.1(0.8, 1.4) 1.43(1.22, 1.68) 1.01 (0.674, 1.50)
  1. aGeometric mean (95% confidence interval), bMedian (min, max), cHarmonic mean (jack-knife SD), dHarmonic mean (pseudo SD), eGeometric mean ratio (90% confidence interval).