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Table 1 Modulation of drug resistance to Dox by Verapamil and Cyclosporine A in HMECd1 and HMECd2

From: Induction of acquired drug resistance in endothelial cells and its involvement in anticancer therapy

  HMEC-1 HMECd1 HMECd2
Agents IC50 (μM) IC50 (μM) RI RF IC50 (μM) RI RF
Dox 0.052 ± 0.001 0.785 ± 0.049 15.09* 1.00 1.257 ± 0.055 24.17* 1.00
+ Vrp 1 μM 0.051 ± 0.002 0.386 ± 0.075 7.56* 1.99* 0.225 ± 0.062 4.41* 5.59*
+ CysA 2.5μM 0.049 ± 0.004 0.251 ± 0.041 5.12* 3.13* 0.159 ± 0.057 3.24* 7.91*
  1. The cells were treated as described and tested by MTS assay. The resistance index (RI) was determined as the IC50 of Dox-treated HMECd1 or HMECd2 cells divided by the IC50 of Dox-treated HMEC-1 cells. The resistance fold (RF) was calculated as the IC50 of Dox-treated HMECd1 or HMECd2 cells over the IC50 of the same cell line as treated by Dox plus P-gp inhibitors. *p <0.05 for statistical significance.