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Table 1 Modulation of drug resistance to Dox by Verapamil and Cyclosporine A in HMECd1 and HMECd2

From: Induction of acquired drug resistance in endothelial cells and its involvement in anticancer therapy

 

HMEC-1

HMECd1

HMECd2

Agents

IC50 (μM)

IC50 (μM)

RI

RF

IC50 (μM)

RI

RF

Dox

0.052 ± 0.001

0.785 ± 0.049

15.09*

1.00

1.257 ± 0.055

24.17*

1.00

+ Vrp 1 μM

0.051 ± 0.002

0.386 ± 0.075

7.56*

1.99*

0.225 ± 0.062

4.41*

5.59*

+ CysA 2.5μM

0.049 ± 0.004

0.251 ± 0.041

5.12*

3.13*

0.159 ± 0.057

3.24*

7.91*

  1. The cells were treated as described and tested by MTS assay. The resistance index (RI) was determined as the IC50 of Dox-treated HMECd1 or HMECd2 cells divided by the IC50 of Dox-treated HMEC-1 cells. The resistance fold (RF) was calculated as the IC50 of Dox-treated HMECd1 or HMECd2 cells over the IC50 of the same cell line as treated by Dox plus P-gp inhibitors. *p <0.05 for statistical significance.
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Journal of Hematology & Oncology

ISSN: 1756-8722

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