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Table 2 Correlation of DWI and MRP parameters with clinical outcome in HCC and tumor thrombus

From: Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy

   Baseline   Percent changes (%)  
Parameters SD or PR PD P value SD or PR PD P value
(Median, Range) (Median, Range) (Median, Range) (Median, Range)
RECIST       
HCC (cm) 9.50, 2.30 ~ 17.00 10.30, 4.30 ~ 10.3 0.255 1.15, –43.48 ~ 8.46 33.98, 20.71 ~ 58.23 0.0002
Tumor thrombus(mm) 26.42, 22.14 ~ 30.70 31.48, 24.65 ~ 38.34 0.110 −10.22, –25.62 ~ 10.26 7.72, –28.52 ~ 42.92 0.260
mRECIST       
HCC (cm) 10.14, 2.15 ~ 19.56 6.12, 2.24 ~ 15.86 0.290 1.94, –19.80 ~ 15.86 0.49, –19.84 ~ 6.70 0.360
DWI       
HCC ADC (×10 -3 mm 2 /s) 0.86, 0.58 ~ 0.99 0.93, 0.8 ~ 1.09 0.15 22.42, –8.99 ~ 51.72 22.22, –12.84 ~ 25.81 0.300
Tumor thrombus ADC (×10 -3 mm 2 /s) 0.66, 0.60 ~ 0.73 0.96, 0.79 ~ 1.14 0.290 13.34, –13.28 ~ 39.94 20.32, –62.33 ~ 114.23 0.140
MRP       
HCC Ktrans (min −1 ) 2.35, 0.90 ~ 4.81 1.29, 1.00 ~ 2.80 0.402 −54.98, –83.37 ~ –10.00 −17.83, –72.09 ~ –6.00 0.014
Kep (min −1 ) 4.25, 1.00 ~ 41.75 1.54, 1.00 ~ 3.01 0.18 −54.73,– 96.32 ~ −5.04 −12.19, –70.17 ~ 28.04 0.048
EVF 0.83, 0.34 ~ 1.00 0.95, 0.84 ~ 1.00 0.065 −2.38, –47.50 ~ 61.76 -6.45, –27.37 ~ –2.38 0.331
Tumor thrombus Ktrans (min −1 ) 1.96, 0.93 ~ 2.99 1.73, 1.05 ~ 2.41 0.350 −55.00, –72.65 ~ −47.35 −20.04, –63.23 ~ 24.14 0.006
Kep (min −1 ) 2.54, 1.05 ~ 4.03 1.97, 1.18 ~ 2.76 0.230 −45.53, –67.42 ~ −23.64 −30.58, –80.01 ~ 18.98 0.090
EVF 0.81, 0.70 ~ 0.92 0.89, 0.82 ~ 0.98 0.110 −15.70, –31.95 ~ 0.56 −29.65, –38.12 ~ −21.07 0.060
  1. Abbreviations: Ktrans Transfer constant; Kep Rate constant; EVF Extracellular volume fraction; ADC Apparent diffusion coefficient; SD Partial disease; PR Partial response; PD Progressive disease.