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Table 2 Correlation of DWI and MRP parameters with clinical outcome in HCC and tumor thrombus

From: Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy

  

Baseline

 

Percent changes (%)

 

Parameters

SD or PR

PD

P value

SD or PR

PD

P value

(Median, Range)

(Median, Range)

(Median, Range)

(Median, Range)

RECIST

      

HCC (cm)

9.50, 2.30 ~ 17.00

10.30, 4.30 ~ 10.3

0.255

1.15, –43.48 ~ 8.46

33.98, 20.71 ~ 58.23

0.0002

Tumor thrombus(mm)

26.42, 22.14 ~ 30.70

31.48, 24.65 ~ 38.34

0.110

−10.22, –25.62 ~ 10.26

7.72, –28.52 ~ 42.92

0.260

mRECIST

      

HCC (cm)

10.14, 2.15 ~ 19.56

6.12, 2.24 ~ 15.86

0.290

1.94, –19.80 ~ 15.86

0.49, –19.84 ~ 6.70

0.360

DWI

      

HCC

ADC (×10 -3 mm 2 /s)

0.86, 0.58 ~ 0.99

0.93, 0.8 ~ 1.09

0.15

22.42, –8.99 ~ 51.72

22.22, –12.84 ~ 25.81

0.300

Tumor thrombus

ADC (×10 -3 mm 2 /s)

0.66, 0.60 ~ 0.73

0.96, 0.79 ~ 1.14

0.290

13.34, –13.28 ~ 39.94

20.32, –62.33 ~ 114.23

0.140

MRP

      

HCC

Ktrans (min −1 )

2.35, 0.90 ~ 4.81

1.29, 1.00 ~ 2.80

0.402

−54.98, –83.37 ~ –10.00

−17.83, –72.09 ~ –6.00

0.014

Kep (min −1 )

4.25, 1.00 ~ 41.75

1.54, 1.00 ~ 3.01

0.18

−54.73,– 96.32 ~ −5.04

−12.19, –70.17 ~ 28.04

0.048

EVF

0.83, 0.34 ~ 1.00

0.95, 0.84 ~ 1.00

0.065

−2.38, –47.50 ~ 61.76

-6.45, –27.37 ~ –2.38

0.331

Tumor thrombus

Ktrans (min −1 )

1.96, 0.93 ~ 2.99

1.73, 1.05 ~ 2.41

0.350

−55.00, –72.65 ~ −47.35

−20.04, –63.23 ~ 24.14

0.006

Kep (min −1 )

2.54, 1.05 ~ 4.03

1.97, 1.18 ~ 2.76

0.230

−45.53, –67.42 ~ −23.64

−30.58, –80.01 ~ 18.98

0.090

EVF

0.81, 0.70 ~ 0.92

0.89, 0.82 ~ 0.98

0.110

−15.70, –31.95 ~ 0.56

−29.65, –38.12 ~ −21.07

0.060

  1. Abbreviations: Ktrans Transfer constant; Kep Rate constant; EVF Extracellular volume fraction; ADC Apparent diffusion coefficient; SD Partial disease; PR Partial response; PD Progressive disease.