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Table 4 Correlation between changes in MRI parameters and plasma biomarkers after sunitinib treatment (Kendall’s τ correlation coefficients)

From: Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy

Kendall’s τ Ktrans Kep EVF ADC
VEGF 0.00* 0.11 0.03 0.24
P- value 1.00 0.49 0.86 0.13
PlGF 0.00 0.10 −0.06 0.06
P- value 0.74 0.53 0.72 0.72
sVEGFR1 0.22 0.18 −0.16 −0.16
P- value 0.16 0.26 0.30 0.30
sVEGFR2 0.33 0.35 −0.05 −0.19
P- value 0.044 0.030 0.77 0.24
sVEGFR3 0.00 −0.09 0.24 −0.23
P- value 1.00 0.62 0.21 0.22
VEGF-C 0.17 0.17 0.02 −0.01
P- value 0.28 0.29 0.90 0.95
bFGF 0.17 0.15 0.01 −0.06
P- value 0.28 0.45 0.86 0.72
TNF-α 0.32 0.34 0.01 −0.17
P- value 0.051 0.030 0.97 0.30
SDF1α 0.02 0.14 0.12 0.26
P- value 0.90 0.38 0.47 0.10
IL-1β 0.16 0.14 0.16 −0.02
P- value 0.33 0.38 0.31 0.90
IL-6 0.01 −0.04 −0.04 −0.13
P- value 0.95 0.82 0.82 0.44
IL-8 0.10 0.08 0.04 −0.21
P- value 0.56 0.63 0.82 0.19
Sol c-KIT 0.20 0.12 −0.01 0.01
P- value 0.20 0.45 0.95 0.95
  1. *Positive values of Kendall’s τ indicate a direct correlation between changes after treatment (relative to baseline) in imaging biomarkers and plasma biomarkers.