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Table 1 Summary of clinical data of patients used in the present study

From: Protein biomarkers distinguish between high- and low-risk pediatric acute lymphoblastic leukemia in a tissue specific manner

Inv.

Assigned code

Gender

Diagnosis

Age at diagnosis (yrs)

Survival

Survival time (yrs)

(WBC) [x103/ul]

TEL/AML1

BCR/ABL

MLL

Karyotype

RISK

MRD

Clinical outcome

1

X1

F

common

2.43

1

2.93

1200.00

-

-

-

 

L

-

CR

2

X2

M

common

4.07

1

2.75

3570.00

-

-

-

46XY

L

-

CR

3

X3

F

common

4.10

1

3.15

5700.00

-

+

-

46ΧΧ, one clone with chromosome 7 t(1;19)

H

-

CR

4

X4

M

common

2.75

2

1.12

48000.00

+

-

-

46ΧΥ, ΤδΤ-

H

-

CR

5

X5

M

common

7.77

1

3.01

18800.00

-

-

-

46XY

H

-

CR

6

X6

M

pro-B

2.35

1

6.47

4400.00

-

-

-

trisomy 4, 6,18,22. X trisome in 5 metaphases

H

-

CR

7

X7

M

common

5.13

1

4.36

13800.00

-

-

-

 

L

-

CR

8

X8

M

common

2.19

2

0.45

7100.00

-

-

-

 

H

-

CR

9

X9

M

common

5.28

1

0.63

8050.00

-

-

-

 

L

-

CR

10

X10

M

common

1.83

2

3.84

58600.00

-

-

-

50ΧΥ, , +Χ, t(5;7)(p11;q11), +14,add(14)(p11.1)+21,+21[13]/46,XY[1], hyperdiploidy: trisomy 14, 21, 22, Χ, total chromosomes 50, in one metaphase, 51 chromosomes with tetrasome 21

H

-

Relapse

11

X11

F

pre-B

4.08

1

2.54

1220.00

-

-

-

 

L

-

CR

12

X12

F

common

6.72

1

4.05

67980.00

-

-

-

46ΧΧ

H

-

CR

13

X13

F

common

2.94

1

3.79

 

+

-

-

46ΧΧ

L

-

CR

14

X14

F

common

1.01

1

3.32

42000.00

-

-

-

 

H

-

CR

15

X15

F

common

5.80

1

4.99

4370.00

-

-

-

56XX, trisomy 4,6,8,10,11,14,15, tetrasomy 21,

H

-

CR

16

X16

F

common

6.05

2

1.82

137000.00

-

+

-

46XX, t(9;22)(q34;q1) mutual translocation between chromosomes 9 +1, chromosome 22, BCR/ABL: 92%

H

-

CR

17

X17

M

pre-B

14.85

2

1.54

92960.00

-

+

-

45ΧΥ, BCR/ABL 97,2%+ MLL- TEL/AML1-

H

-

CR

18

X18

M

common

1.93

1

4.76

5600.00

-

-

-

59XXY, hyperdiploidy +4,+6,+8,+29,+10,+11,+15,+17,+20,+21*2,

H

-

CR

19

X19

M

common

2.02

1

5.01

1380.00

-

-

-

46XY

L

-

CR

20

X20

F

common

2.23

1

2.11

9670.00

-

-

-

 

L

-

CR

21

X21

F

common

2.86

1

4.50

14700.00

-

-

-

 

L

-

CR

22

X22

F

common

3.30

1

2.67

30820.00

+

-

-

 

L

-

CR

23

X23

M

common

 

1

2.56

 

-

-

-

 

H

-

CR

24

X24

M

common

14.04

2

3.11

670.00

-

-

-

 

H

-

Relapse

25

X25

F

common

4.41

1

5.00

10440.00

-

-

-

 

L

-

CR

26

X26

F

common

13.72

1

3.09

4000.00

+

-

-

46XX, t(1;19)(q23p13)83,7%

H

-

CR

27

X27

F

common

14.41

1

4.56

2220.00

-

-

-

55XX+X, +4,+8, +14, +17, +18, +21 [8]/46XX[2]

H

-

CR

28

X28

M

common

2.92

1

2.09

8100.00

-

-

-

 

L

-

CR

29

X29

F

common

5.25

1

4.37

6520.00

+

-

-

46ΧΧ

L

-

CR

30

X30

F

L3

5.49

1

4.03

3700.00

-

-

-

49XX, xx,+4, +21,/46XX

H

-

CR

31

X31

F

common

-0.70

1

3.86

74800.00

-

-

+

46XX

H

-

CR

32

X32

F

common

4.97

2

1.42

10610.00

-

-

-

46XX

L

-

CR

33

X33

F

common

6.97

1

4.11

4000.00

-

-

-

 

H

-

CR

34

X34

M

common

7.86

1

4.02

10270.00

+

-

-

46 XY

L

-

CR

35

X35

F

pro-B

3.23

1

3.46

22900.00

+

-

-

46xx, , TEL/AML1: 97.3%, E2A'+

L

-

CR

36

X36

M

common

2.87

1

4.15

6670.00

+

-

-

 

L

-

CR

37

X37

M

common

14.21

1

2.75

21000.00

-

+

-

46XY, 1(q)(q0) del13 del19 t(1;19)-del13, BCR/ABL 90,7%+ TCF3E2A/PBX1 (1;19) 95%+

H

-

CR

38

X38

M

common

7.47

1

3.50

55050.00

-

-

-

 

H

-

CR

39

X39

M

common

13.61

1

7.75

 

-

-

-

 

H

-

CR

40

X40

F

common

3.13

1

4.08

17000.00

-

-

-

 

L

-

CR

41

X41

M

common

1.75

1

2.93

4400.00

+

-

-

Tcf3 (E2A)-, AML1: 4 copies (+)50%

L

+

CR

42

X42

F

pro-B

9.31

1

3.04

3000.00

+

-

-

TEL/AML(78,7%)

H

-

CR

43

X43

M

common

1.01

1

3.57

8800.00

-

-

+

48XY+X mutual translocation 11 or 19. 1 extra Χ, translocation between 2 Η 9, 1 extra chromosome 6, MLL 92%

H

-

CR

44

X44

F

common

0.16

1

3.84

84000.00

-

-

+

46XX, MLL:95.8%,

H

+

CR

45

X45

F

common

3.22

2

2.52

33280.00

+

-

-

46ΧΧ/49ΧΧ,+Χ, +10 +21 ΤΕL/AML96,6%

H

-

CR

  1. (Legends: Inv: Invoice, Assigned Code: Internal patient laboratory code,Survival: 1: Alive, 2: Deceased, MRD: Minimal Residual Disease) MRD detection at the end of induction (28th day), Risk: L:Low, H:High.
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Journal of Hematology & Oncology

ISSN: 1756-8722

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