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Table 2 Protein expression levels and GO annotation

From: Protein biomarkers distinguish between high- and low-risk pediatric acute lymphoblastic leukemia in a tissue specific manner

A

 

BMC/ALL

PBC/ALL

PBP/HR-ALL

PBP/LR-ALL

BMP/HR-ALL

BMP/LR-ALL

A1AT

0.93

0.00

0.00

0.00

1.34

0.97

A2MG

0.96

0.00

0.00

0.00

0.00

0.57

ACTB

1.62

0.00

0.00

0.00

0.00

0.00

ACTB

0.00

0.86

0.00

0.00

-0.53

0.00

ACTC

0.00

0.00

0.00

0.00

0.97

0.00

ACTG

0.00

0.00

0.00

0.00

-0.63

0.00

ACTS

0.00

0.00

0.00

0.00

0.87

0.00

AFAM

0.00

0.00

0.00

0.00

0.00

-1.00

AFM

0.00

0.00

0.00

-1.49

0.00

0.00

AMBP

0.00

0.00

0.57

0.00

0.86

0.00

ANGT

0.00

0.00

0.00

0.00

0.00

1.58

ANT3

0.00

0.00

0.00

0.00

1.00

0.75

APOA1

1.03

1.67

0.00

0.00

1.20

0.00

APOA4

0.00

0.00

0.00

0.00

0.91

0.00

APOC2

0.00

0.00

0.00

0.00

0.82

1.50

APOE

0.00

0.00

0.00

0.00

1.36

1.05

BICR1

0.00

0.00

0.00

0.00

0.00

0.88

CALL5

0.00

0.00

0.00

0.00

1.34

0.00

CATA

0.00

1.49

0.00

0.00

0.00

0.00

CERU

1.37

1.58

0.00

0.00

0.70

0.00

CFAB

0.00

0.00

0.00

0.00

1.21

1.27

CH60

0.00

0.00

0.00

0.00

0.00

0.00

CLUS

0.00

0.00

0.00

0.00

0.45

0.00

ENOA

0.00

0.00

0.00

0.00

1.19

1.07

ENOB

0.00

0.00

0.00

0.00

0.00

0.93

FCN3

0.00

0.00

0.00

0.00

1.36

0.00

FHR1

0.00

0.00

0.00

0.00

0.68

0.00

FIBA

0.00

0.00

0.00

0.00

0.89

0.80

FIBB

1.67

1.13

0.00

0.00

1.00

0.70

FIBG

1.42

1.04

0.00

0.00

1.11

1.29

G3P

0.00

0.00

0.00

0.00

0.00

0.61

GELS

0.00

0.00

-1.22

0.00

-0.82

0.00

HEMO

0.93

0.83

0.00

0.00

0.00

1.11

HPT

1.34

1.58

0.00

0.00

0.00

0.90

IGHG1

1.11

1.06

0.00

0.00

0.00

-0.87

IGHG2

1.67

1.00

0.00

0.00

0.00

0.00

KNG1

0.00

0.00

0.00

1.53

0.00

1.30

KPYM

0.00

0.00

0.00

0.00

1.40

1.05

PLMN

0.00

0.00

0.00

0.00

0.00

0.89

PRDX1

0.00

0.00

0.00

0.00

0.00

1.32

PSME1

0.00

0.00

0.00

0.00

0.00

1.00

S10A9

-0.67

-1.27

0.00

0.00

-1.37

-1.65

SAA

1.39

0.89

0.00

0.00

1.40

0.81

THRB

0.00

0.00

0.00

0.00

0.43

0.00

TRFE

1.07

1.41

0.00

0.00

1.53

0.00

TTHY

0.96

0.00

0.00

0.00

1.53

1.06

UBQL1

0.00

0.00

0.00

0.00

-1.11

0.00

VTDB

0.00

0.00

0.00

0.00

0.58

1.31

VTNC

0.00

0.00

0.00

0.00

0.00

-1.04

ZA2G

0.00

0.00

0.00

0.00

1.00

0.97

B

biological process----triglyceride-rich lipoprotein particle remodeling----GO:0034370

C=11;O=4;E=0.01;R=373.25;rawP=1.85e-10;adjP=2.12e-08

APOE

apolipoprotein E

APOC2

apolipoprotein C-II

APOA4

apolipoprotein A-IV

APOA1

apolipoprotein A-I

biological process----phospholipid efflux----GO:0033700

C=10;O=4;E=0.01;R=410.57;rawP=1.18e-10;adjP=2.12e-08

APOE

apolipoprotein E

APOC2

apolipoprotein C-II

APOA4

apolipoprotein A-IV

APOA1

apolipoprotein A-I

biological process----very-low-density lipoprotein particle remodeling----GO:0034372

C=11;O=4;E=0.01;R=373.25;rawP=1.85e-10;adjP=2.12e-08

APOE

apolipoprotein E

APOC2

apolipoprotein C-II

APOA4

apolipoprotein A-IV

APOA1

apolipoprotein A-I

biological process----reverse cholesterol transport----GO:0043691

C=16;O=4;E=0.02;R=256.61;rawP=1.02e-09;adjP=8.77e-08

APOE

apolipoprotein E

APOC2

apolipoprotein C-II

APOA4

apolipoprotein A-IV

APOA1

apolipoprotein A-I

biological process----regulation of cholesterol transport----GO:0032374

C=20;O=4;E=0.02;R=205.29;rawP=2.71e-09;adjP=1.28e-07

APOE

apolipoprotein E

APOC2

apolipoprotein C-II

APOA4

apolipoprotein A-IV

APOA1

apolipoprotein A-I

biological process----regulation of sterol transport----GO:0032371

C=20;O=4;E=0.02;R=205.29;rawP=2.71e-09;adjP=1.28e-07

APOE

apolipoprotein E

APOC2

apolipoprotein C-II

APOA4

apolipoprotein A-IV

APOA1

apolipoprotein A-I

biological process----plasma lipoprotein particle remodeling----GO:0034369

C=21;O=4;E=0.02;R=195.51;rawP=3.34e-09;adjP=1.28e-07

APOE

apolipoprotein E

APOC2

apolipoprotein C-II

APOA4

apolipoprotein A-IV

APOA1

apolipoprotein A-I

biological process----macromolecular complex remodeling----GO:0034367

C=21;O=4;E=0.02;R=195.51;rawP=3.34e-09;adjP=1.28e-07

APOE

apolipoprotein E

APOC2

apolipoprotein C-II

APOA4

apolipoprotein A-IV

APOA1

apolipoprotein A-I

biological process----protein-lipid complex remodeling----GO:0034368

C=21;O=4;E=0.02;R=195.51;rawP=3.34e-09;adjP=1.28e-07

APOE

apolipoprotein E

APOC2

apolipoprotein C-II

APOA4

apolipoprotein A-IV

APOA1

apolipoprotein A-I

biological process----cholesterol efflux----GO:0033344

C=25;O=4;E=0.02;R=164.23;rawP=7.05e-09;adjP=2.43e-07

APOE

apolipoprotein E

APOC2

apolipoprotein C-II

APOA4

apolipoprotein A-IV

APOA1

apolipoprotein A-I

  1. (A) Summary of protein expression values with respect to samples, stratified as high- or low-risk. The values under each sampling category represent the log2 transformed ratio of the samples evaluated over control samples. The value 0 signifies that the protein was not detected in the respective group of samples (BMP/HR, Bone marrow plasma/high risk, BMC, Bone marrow cells; PBC, Peripheral blood cells; PBP/HR, Peripheral blood plasma/high risk; PBP/LR, Peripheral blood plasma/low risk; BMP/LR, Bone marrow plasma/low risk). (B) Part two includes the respective proteins by using their gene symbol sorted by their function as revealed by gene ontology (GO) analysis.