Table 2 Selected strategies using epigenetic tools for leukemia diagnostic as proposed in the International Database for Patents of Inventions

Detection of five point mutations in HDAC1: M51L, Q111K, T114A, V157G and a premature stop codon at R34

Detection of one or more mutations, mainly at Arg-882

Detection of expression levels or mutations in this putative suppressor gene

Analysis of methylation state of a target gene in this chromosomal region

Detection of bi allelic mutations in CCAAT-enhancer binding protein gene