Skip to main content
Figure 5 | Journal of Hematology & Oncology

Figure 5

From: IGF binding protein 2 is a cell-autonomous factor supporting survival and migration of acute leukemia cells

Figure 5

Knockout of IGFBP2 decreases migration of leukemia cells out of bone marrow in the AML1-ETO mouse AML model. (A-B) Representative flow cytometry plots (A) and summary of results (B) showing the mice transplanted with IGFBP2-null AML cells have significantly decreased GFP+ AML cells in peripheral blood, liver, and spleen but not in BM compared with the mice transplanted with control AML cells. (C) The IGFBP2-null AML BM cells have decreased expression of a number of surface proteins compared to wild-type cells (nā€‰=ā€‰3; * pā€‰<ā€‰0.05).

Back to article page