Skip to main content
Figure 4 | Journal of Hematology & Oncology

Figure 4

From: Clinical significance of cytogenetic aberrations in bone marrow of patients with diffuse large B-cell lymphoma: prognostic significance and relevance to histologic involvement

Figure 4

Prognoses according to specific chromosomal abnormalities. (A) Forest plots showing hazard ratios obtained by univariate Cox analysis for overall survival (OS) and progression-free survival (PFS) according to the presence of specific chromosomal abnormalities using patients with lymphoma bone marrow involvement and normal karyotype as a reference group in 327 patients having either abnormal karyotypes or histologic BM involvement. (B) Based on a cluster analysis of 33 frequent numerical abnormalities and breakpoints, 138 patients with ≥ 2 chromosomal abnormalities were segregated into clusters with characteristic abnormality patterns. The horizontal labels indicate clusters (red, Cluster 1; yellow, Cluster 2; green, Cluster 3; blue, Cluster 4; cyan, Cluster 5; purple, Cluster 6; and black, Cluster 7). The characteristic loci of the abnormalities in each cluster are indicated in red, and the loci associated with a poor prognosis in the univariate analysis are indicated in blue in the right panel. (C) The (OS) and PFS of each cluster is plotted.

Back to article page

Journal of Hematology & Oncology

ISSN: 1756-8722

Contact us