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Figure 2 | Journal of Hematology & Oncology

Figure 2

From: Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs

Figure 2

Knock-down of Shh sensitizes A549M cells to standard therapies. Cell proliferation of A549M cells was significantly reduced after treatment with erlotinib (A) and cisplatin (B) following Shh knock-down. Cells were first treated with vehicle (A549M-control) or with specific si-RNA against Shh (A549M-siShh) for 48 hours and then with indicated concentrations of erlotinib/cisplatin for 24 hours. Parental A549 cells were included as a control to verify the induced resistance of A549M cells to erlotinib/cisplatin. All the plotted values are relative to vehicle-treated A549 cells. *p<0.05 and **p<0.01.

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