Figure 3

Hedgehog inhibitor, GDC-0449 (GDC) sensitizes A549M as well as H1299 cells to standard therapies. Pre-treatment with GDC-0449 (20nM) markedly reduced cell proliferation of A549M cells (A549M-GDC) (A-B) as well as H1299 cells (H1299-GDC) (C-D), compared to vehicle treated respective control cells, when they were exposed to erlotinib or cisplatin for 72 hours. Control A549 cells did not exhibit such sensitization (A-B). All the plotted values are relative to vehicle-treated cells.