| Dose at time of decline in platelet count | Maximum dose based on platelet count after prior treatment interruption or dose reduction | ||||
---|---|---|---|---|---|---|
25 mg BID | 20 mg BID | 15 mg BID | 10 mg BID | 5 mg BID | ||
Current platelet count | New dose to be used | |||||
≥125 × 109/L | No change | No change | No change | No change | No change | 20 mg BID |
100 to <125 × 109/L | 20 mg BID | 15 mg BID | No change | No change | No change | 15 mg BID |
75 to <100 × 109/L | 10 mg BID | 10 mg BID | 10 mg BID | No change | No change | 10 mg BID for 2 weeks; if stable, may increase to 15 mg BID |
50 to <75 × 109/L | 5 mg BID | 5 mg BID | 5 mg BID | 5 mg BID | No change | 5 mg BID for 2 weeks; if stable, may increase to 10 mg BID |
<50 × 109/L | Hold | Hold | Hold | Hold | Hold | Continue holding |