Figure 7

Deletion of the N-12 aas markedly reduces SALL4B mediated LSK cell expansion. (a) Full length (FL) and N-terminal 12 aas deleted (δΝ12) SALL4B protein. (b) N-12 aas are essential for recruiting DNMT activities. (c) IP in LSK cells shows N-12 aas are required for SALL4B/DNMT1 interaction. (d) Growth curve of mouse LSK cells transduced with FL-SALL4B, δΝ12-SALL4B or GFP lentivirus construct.