Table 1 Phosphatidylinositol-3 kinase genes and proteins
From: Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics
Class | Gene | Chromosomal location | Protein | Mass (kDa) | Sequence length (AA) |
|---|---|---|---|---|---|
Class I | Â | Â | Â | Â | Â |
 IA | PIK3CA | 3q26.3 | p110-α | 124.28 | 1068 |
|  | PIK3CB | 3q22.3 | p110-β | 122.76 | 1070 |
|  | PIK3CD | 1p36.2 | p110-δ | 119.48 | 1044 |
|  | PIK3R1 | 5q13.1 | p85-α | 83.60 | 724 |
|  | PIK3R2 | 19p13.1 | p85-β | 81.55 | 728 |
|  | PIK3R3 | 1p34.1 | p55-γ | 54.45 | 461 |
 IB |  |  |  |  |  |
|  | PIK3CG | 7q22.3 | π110-γ | 126.45 | 1102 |
| Â | PIK3R5 | 17p13.1 | p101 | 97.35 | 880 |
| Â | PIK3R6 | 17p13.1 | p84/p87PIKAP | 84.26 | 754 |
Class II | Â | Â | Â | Â | Â |
|  | PIK3C2A | 11p15.1 | PIK-C2α | 190.68 | 1686 |
|  | PIK3C2B | 1q32.1 | PIK-C2β | 184.77 | 1634 |
|  | PIK3C2G | 12p12.3 | PIK-C2γ | 165.72 | 1445 |
Class III | Â | Â | Â | Â | Â |
| Â | PIK3C3 | 18q12.3 | hVps34 | 101.55 | 887 |
| Â | PIK3R4 | 3q22.1 | p150 | 153.10 | 1358 |