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Table 2 SNPs showing significant genotypic associations with myelodysplastic syndromes

From: DNA repair gene variants are associated with an increased risk of myelodysplastic syndromes in a Czech population

Gene Name Gene location dbSNPs reference number Gene region Genotype MAF database MAF controls MAF patients OR 95% confidence interval P Value
SLC4A2 solute carrier family 4, anion exchanger, member 2 7q36.1 rs13240966 intron C/G 0.227 0.4829 0.7110 2.63 1.94-3.63 7.00E-11
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 7q21.12 rs2235074 intron A/G 0.031 0.0575 0.1569 3.05 1.88-4.97 8.65E-07
LIG1 ligase I, DNA, ATP-dependent 19q13.2-q13.3 rs20580 coding A/C 0.513 0.2216 0.3665 2.03 1.50-2.75 1.65E-06
ROS1 c-ros oncogene 1 , receptor tyrosine kinase 6q22 rs574664 intron T/A 0.145 0.1432 0.2593 2.10 1.48-3.00 1.24E-05
PGR progesterone receptor 11q22-q23 rs1042838 coding T/G 0.199 0.1601 0.2804 2.05 1.46-2.87 1.46E-05
STK6 aurora kinase A 20q13 rs732417 5UTR C/G 0.083 0.1051 0.1995 2.12 1.43-3.16 7.76E-05
GPX3 glutathione peroxidase 3 5q23 rs8177426 intron A/G 0.217 0.2288 0.3567 1.87 1.37-2.55 4.26E-05
RAD52 RAD52 homolog 12p13-p12.2 rs11226 3UTR T/C 0.224 0.2308 0.3509 1.80 1.31-2.48 1.70E-04
MSH3 mutS homolog 3 5q11-q12 rs3797896 intron G/C 0.066 0.0627 0.0131 0.20 0.07-0.54 2.16E-04
  1. MAF: minor allele frequency; MAF database: Caucasian/European frequencies; OR: odds ratio.