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Table 3 Association between individual SNPs and MDS

From: DNA repair gene variants are associated with an increased risk of myelodysplastic syndromes in a Czech population

SNP Genotype Controls N (%) Cases N (%) OR (95% CI) p-Values
rs13240966 SLC4A2 235 173   
  GG 72 (30.64) 22(12.72) 1.0 (Ref)  
  CC 64 (27.23) 95 (57.91) 4.86 (2.74-8.62) < 0.0001
  CG 99 (42.13) 56 (32.37) 1.85 (1.04-3.30) 0.04
  CC + CG 163 (69.36) 151 (87.28) 3.03 (1.79-5.13) < 0.0001
rs2235074 ABCB1 261 188   
  GG 232 (88.55) 129 (68.62) 1.0 (Ref)  
  AA 1 (0.38) 0 (0.00) NA  
  AG 28 (10.69) 59 (31.38) 3.79 (2.30-6.24) < 0.0001
  AA + AG 29 (11.07) 59 (31.38) 3.66 (2.23-6.00) < 0.0001
rs20580 LIG1 264 191   
  CC 167 (63.26) 84 (43.98) 1.0 (Ref)  
  AA 20 (7.58) 33 (17.28) 3.28 (1.77-6.06) < 0.0001
  AC 77 (29.17) 74(38.74) 1.91 (1.26-2.89) 0.002
  AA + AC 97 (36.74) 110 (57.59) 2.25 (1.54-3.29) < 0.0001
rs574664 ROS1 262 189   
  TT 191 (72.90) 95 (50.26) 1.0 (Ref)  
  AA 4 (1.53) 4 (2.12) 2.01 (0.49-8.22) 0.32
  TA 67 (25.57) 90 (47.62) 2.70 (1.81-4.03) < 0.0001
  AA + TA 71 (27.10) 94 (49.74) 2.66 (1.79-3.95) < 0.0001
rs732417 STK6 257 188   
  GG 203 (78.99) 113 (60.11) 1.0 (Ref)  
  CC 0 (0.00) 2 (1.06) NA  
  CG 54 (21.01) 73 (38.83) 2.43 (1.60-3.70) < 0.0001
  CC + CG 54 (21.01) 75 (39.89) 2.50 (1.61-3.88) < 0.0001
rs1042838 PGR 253 189   
  GG 174 (68.77) 86 (45.50) 1.0 (Ref)  
  TT 2 (0.79) 3 (1.59) 3.04 (0.40-26.49) 0.34
  TG 77 (30.43) 100 (52.91) 2.63 (1.74-3.97) < 0.0001
  TT + TG 79 (31.23) 103 (54.50) 2.64 (1.75-3.98) < 0.0001
rs8177426 GPX3 260 171   
  GG 155 (59.62) 82 (47.95) 1.0 (Ref)  
  AA 14 (5.38) 33(19.30) 4.46 (2.16-9.32) < 0.0001
  AG 91 (35.00) 56 (32.75) 1.16 (0.74-1.82) 0.51
  AA + AG 105 (40.38) 92 (53.80) 1.66 (1.10-2.47) 0.01
rs11226 RAD52 234 171   
  CC (61.11) 83 (48.54) 1.0 (Ref)  
  TT 17 (7.26) 32 (18.71) 3.24 (1.62-6.53) 0.0002
  TC 74 (31.62) 56 (32.75) 1.30 (0.82-2.07) 0.26
  TT + TC 91 (38.88) 90 (52.63) 1.70 (1.15-2.54) 0.01
rs3797896 MSH3 262 191   
  CC 232 (88.21) 186 (97.38) 1.0 (Ref)  
  GG 3 (1.14) 0 (0.00) NA  
  GC 27 (10.27) 5 (2.62) 0.23 (0.09-0.61) 0.001
  GG + GC 30 (11.40) 5 (2.62) 0.21 (0.08-0.55) 0.001