Table 2 Adverse events, according to CTC grades, occurring in >10% of patients
Toxicity | Patients | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|---|
n | n (%) | n (%) | n (%) | n (%) | |
Alopecia | 30 | 18 (60.0) | 11 (36.7) | 0 | 0 |
Fatigue and asthenia | 30 | 14 (46.7) | 14 (46.7) | 0 | 0 |
Sensory neuropathy | 30 | 9 (30.0) | 4 (13.3) | 0 | 0 |
Edema | 30 | 16 (53.3) | 0 | 0 | 0 |
Nausea and vomiting | 30 | 10 (30.0) | 0 | 0 | 0 |
Diarrhea | 30 | 6 (20.0) | 1 (3.3) | 0 | 0 |
Constipation | 30 | 4 (13.3) | 0 | 0 | 0 |
Stomatitis | 30 | 10 (33.3) | 3 (10.0) | 0 | 0 |
Febrile neutropenia | 30 | 0 | 0 | 3 (10.0) | 1 (3.3) |
Skin rash | 30 | 6 (20.0) | 0 | 0 | 0 |
Arthralgia and myalgia | 30 | 4 (13.3) | 1 (3.3) | 0 | 0 |
Perspiration | 30 | 8 (26.7) | 1 (3.3) | 0 | 0 |
Dysgeusia | 30 | 15 (50.0) | 5 (16.7) | 0 | 0 |
Nail changes | 30 | 18 (60.0) | 0 | 0 | 0 |
Hot flush | 30 | 12 (40.0) | 2 (6.7) | 0 | 0 |
Depressive symptoms | 30 | 8 (26.7) | 1 (3.3) | 0 | 0 |
Insomnia | 30 | 8 (26.7) | 0 | 0 | 0 |
Dyspepsia and abdominal pain | 30 | 6 (20.0) | 0 | 0 | 0 |
Sore throat and dysphagia | 30 | 5 (16.7) | 2 (6.7) | 0 | 0 |
Chill | 30 | 4 (13.3) | 0 | 0 | 0 |
Increased urea | 28 | 18 (64.3) | 0 | 0 | 0 |
Increased potassium | 30 | 4 (13.3) | 0 | 0 | 0 |
Hypoproteinemia | 23 | 4 (17.4) | 0 | 0 | 0 |
Increased GGT | 27 | 4 (14.8) | 1 (3.7) | 0 | 0 |
Increased GPT | 27 | 4 (14.8) | 0 | 0 | 0 |
Increased LDH | 22 | 20 (90.9) | 0 | 0 | 0 |
Anemia, day 21 | 25# | 12 (48.0) | 0 | 0 | 0 |
Anemia, day 7 | 21# | 16 (76.2) | 0 | 0 | 0 |
Leucopenia, day 7 | 26 | 5 (19.2) | 4 (15.4) | 10 (38.5) | 4 (15.4) |
Neutropenia, day 7 | 20 | 0 | 1 (5.0) | 4 (20.0) | 14 (70.0) |