Figure 4
As 2 O 3 decreased the proportion of CTCs relative to peripheral blood mononuclear cells (PBMCs) and prolonged survival. (A) Flow cytometry analysis indicated that As2O3 significantly decreased the proportion of CTCs relative to PBMCs, In the Huh7-GFP cell line, the proportions of CTCs relative to PBMCs were 1.292% ± 0.164% in the As2O3 group and 1.758% ± 0.118% in the control group (P = 0.0305), and in the Hep3B-GFP cell line, the corresponding proportions were 0.619% ± 0.050% and 1.235% ± 0.072% (P < 0.0001). (B) In the Huh7-wt cell line, median survival increased from 72.5 to 86.5 days (P = 0.0344), and in the Hep3B-wt cell line, median survival increased from 89.5 to 104 days (P = 0.015).