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Archived Comments for: CD44 standard and CD44v10 isoform expression on leukemia cells distinctly influences niche embedding of hematopoietic stem cells

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  1. Redox stress-induced canonical Wnt signal activation is regulated by CD44 variant isoform.

    Go Yoshida, Tokyo Medical and Dental University

    5 November 2014

    The authors have demonstrated that CD44v10 expression prevented the up-regulation of beta-catenin, c-Myc, cyclinD1, and Lef1 in the co-culture of hematopoietic stem cells (HSCs) with bone marrow stromal cells (BM-Str), thereby maintaining the quiescence of HSCs (Figure7B and C) (1). Given that normal or cancerous tissue stem cells change the proliferative or dormant status depending on the level of oxidative stress in the microenvironment, Yoshida et al. have found out that CD44v8-10-xCT-GSH (glutathione) axis in the epithelial cells is critical in the regulation of redox stress-induced canonical Wnt signal activation, resulting in the up-regulation of beta-catenin, c-Myc, cyclinD1, and Lef1 (2). However, it remains to be known how CD44 standard isoform or CD44v10 influences on the interaction of HSCs and BM-str. Because of the high expression of xCT (cysteine/glutamate co-exchanging transporter) in hematological malignant cells (1, 3), xCT might reduce oxidative stress independently of CD44.

     

    Ref.

    (1) J Hematol Oncol. 2014 Mar 31;7:29.

    CD44 standard and CD44v10 isoform expression on leukemia cells distinctly influences niche embedding of hematopoietic stem cells.

    Erb U, Megaptche AP, Gu X et al.

    (2) Biochem Biophys Res Commun. 2014 Jan 10;443(2):622-7.

    Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation.

    Yoshida GJ, Saya H.

    (3) J Hematol Oncol. 2014 Apr 4;7:30.

    Targeting xCT, a cystine-glutamate transporter induces apoptosis and tumor regression for KSHV/HIV-associated lymphoma.

    Dai L, Cao Y, Chen Y et al.

     

    Competing interests

    No Competing Interests Exist.

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