Figure 2

Monitoring of renal damage in HLA-A*24:02 -transgenic mice following transfer of WT1-specific and HLA-A*24:02-restricted CTLs. (A) Histopathology of the glomeruli of HLA-A*24:02-transgenic mice that had received WT1-specific and HLA-A*24-restricted CTLs and control CTLs. (hematoxylin-eosin stain; original magnification x400). Notably, lymphocyte infiltration and tissue damage are not detectable in the glomerulus of the WT1-specific CTL-transferred mouse. (B) Trafficking of WT1-specific and HLA-A*24:02-restricted CTLs in HLA-A*24:02-transgenic mice. Four mice were transferred with WT1-specific and HLA-A*24:02-restricted CTLs. Notably, CTLs have not accumulated in specific organs, including the kidneys.