Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation

Table 2 Macroscopic organ hemorrhage score and organ infection score per animal (average ± SEM)

Dose (ng/kg)	Total hemorrhage score^a	GI tract hemorrhage score^b	Total infection score^c
0	8.4 ± 1.6	5.6 ± 1.1.4	12.8 ± 2.2
50	5.1 ± 0.63	3.2 ± 0.75	12.3 ± 3.4
100	6.6 ± 0.73	4.5 ± 0.90	10.6 ± 3.7
250	5.0 ± 1.0	3.1 ± 0.78	8.8 ± 3.1
500	5.8 ± 1.1	3.7 ± 0.70	8.2 ± 3.3

^aHemorrhage was assessed on necropsy of found dead or preterminally euthanized animals by a pathologist blinded to the therapy group assignment. The following tissues were included in calculating the mean hemorrhage scores presented in this table: stomach, ileum, jejunum, duodenum, colon, cecum, rectum, heart, brain, kidneys, liver, lungs, urinary bladder). Hemorrhage score was defined as follows: 0 = absence of hemorrhage; 1 = minimal hemorrhage(s); 2 = slight hemorrhage(s); 3 = moderate hemorrhage(s); 4 = marked hemorrhage(s); and 5 = severe hemorrhage(s). In each animal scores for all organs were summed, then mean score for each treatment group was calculated.
^bThe following tissues were included in calculating the GI tract hemorrhage score: stomach, ileum, jejunum, duodenum, colon, cecum, and rectum.
^cFor infection score determination, organ samples were collected on necropsy and cultured (animals found dead excluded from the analysis), including brain, heart, kidney, liver, both lungs, and spleen. Bacterial growth was scored for each organ (from 0 to 4). In each animal scores for all organs were summed, then mean score for each treatment group was calculated.

ISSN: 1756-8722