rHuIL-12 | IFN-γ | IL-18 | IP-10 | |||||
---|---|---|---|---|---|---|---|---|
Dose (ng/kg) | Cmax(pg/mL) | AUC0-t(hr · pg/mL) | Cmax(pg/mL) | AUC0-t(hr · pg/mL) | Cmax(pg/mL) | AUC0-t(hr · pg/mL) | Cmax(pg/mL) | AUC0-t(hr · pg/mL) |
0 | BLQ | BLQ | 150.20 (NR) | 24868.80 (NR) | 1920.75 (1207.67) | 228818.77 (121013.28) | 284.36 (188.72) | 16519.02 (7951.53) |
50 | 14.65 (4.75) | 190.61 (90.51) | 257.73 (120.42) | 6239.20 (5395.40) | 1831.76 (1275.11) | 236796.45 (209796.17) | 1100.67 (316.73) | 43932.87 (29769.36) |
100 | 39.03 (15.85) | 532.72 (238.16) | 709.60 (422.55) | 22904.40 (8449.72) | 2362.16 (1028.21) | 309524.07 (123378.16) | 1422.17 (120.53) | 61099.10 (6735.34) |
250 | 69.49 (11.47) | 1397.30 (203.75) | 1949.15 (1200.24) | 76621.50 (41016.18) | 3037.33 (1339.84) | 391945.00 (150071.03)) | 2313.90 (1289.69) | 78442.31 (17024.71) |
500 | 137.18 (38.07) | 2992.78 (1307.55) | 3094.00 (1195.79) | 123995.40 (42927.08) | 4738.03 (1511.00) | 621328.60 (171280.79) | 3236.52 (3060.21) | 118595.07 (57862.00) |