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Table 3 C max and AUC 0-t of rHuIL-12, IFN-γ, IL-18, and IP-10 after a Single Dose of rHuIL-12 in Irradiated Rhesus Monkeys

From: Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation

 

rHuIL-12

IFN-γ

IL-18

IP-10

Dose (ng/kg)

Cmax(pg/mL)

AUC0-t(hr · pg/mL)

Cmax(pg/mL)

AUC0-t(hr · pg/mL)

Cmax(pg/mL)

AUC0-t(hr · pg/mL)

Cmax(pg/mL)

AUC0-t(hr · pg/mL)

0

BLQ

BLQ

150.20 (NR)

24868.80 (NR)

1920.75 (1207.67)

228818.77 (121013.28)

284.36 (188.72)

16519.02 (7951.53)

50

14.65 (4.75)

190.61 (90.51)

257.73 (120.42)

6239.20 (5395.40)

1831.76 (1275.11)

236796.45 (209796.17)

1100.67 (316.73)

43932.87 (29769.36)

100

39.03 (15.85)

532.72 (238.16)

709.60 (422.55)

22904.40 (8449.72)

2362.16 (1028.21)

309524.07 (123378.16)

1422.17 (120.53)

61099.10 (6735.34)

250

69.49 (11.47)

1397.30 (203.75)

1949.15 (1200.24)

76621.50 (41016.18)

3037.33 (1339.84)

391945.00 (150071.03))

2313.90 (1289.69)

78442.31 (17024.71)

500

137.18 (38.07)

2992.78 (1307.55)

3094.00 (1195.79)

123995.40 (42927.08)

4738.03 (1511.00)

621328.60 (171280.79)

3236.52 (3060.21)

118595.07 (57862.00)

  1. All data are means (standard deviations).
  2. Abbreviations: BLQ-Below the limit of quantitation; AUC, area under the concentration vs. time curve; 0-t, time 0 to time of assessment; hr, hour; NR, not reported due to < 3 animals contributing data.