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Table 1 Clinical features of the 128 DS-ALL and the 4,637 non-DS-ALL patients

From: Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries

Features DS-ALL (%) non-DS-ALL (%) P valuea
Gender    
 Female 63 (49) 2195 (47) 0.67b
 Male 65 (51) 2442 (53)  
Age (years)    
 <1 0 (0) 154 (3.3) 0.029 c
 1-9 95 (74) 3703 (80)  
 10-17 33 (26) 780 (17)  
WBC count (×10 9 /l)    
 0-9 61 (48) 2408 (52) 0.51c
 10-49 50 (39) 1453 (31)  
 >50 17 (13) 776 (17)  
Platelet count (×10 9 /l) d    
 <50 76 (59) 2310 (50) 0.005 c
 50-149 41 (32) 1473 (32)  
 >150 6 (5) 755 (16)  
EMD e    
 CNS 5f (3.9) 125 (2.7) NA
 Mediastinal 4f (3.1) 72 (1.6)  
 Testis 0 (0) 15 (0.6)  
  1. CNS, central nervous system; DS-ALL, Down syndrome-related acute lymphoblastic leukemia; EMD, extramedullary disease; NA, not analyzed due to lack of EMD data in several instances; WBC, white blood cell.
  2. aSignificant P values in bold type.
  3. bChi square test.
  4. cMann-Whitney U test.
  5. dData on platelet counts missing in 5 DS-ALL and in 99 non-DS-ALL patients.
  6. eData on CNS involvement missing in 16 non-DS-ALL patients, on mediastinal mass in one DS-ALL and in 51 non-DS-ALL patients, and on testicular involvement in 27 DS-ALL and in 990 non-DS-ALL patients.
  7. fOne patient had CNS involvement as well as a mediastinal mass.