|
Features
|
DS-ALL (%)
|
non-DS-ALL (%)
|
P valuea
|
|---|
|
Gender
| | | |
|
Female
|
63 (49)
|
2195 (47)
|
0.67b
|
|
Male
|
65 (51)
|
2442 (53)
| |
|
Age (years)
| | | |
|
<1
|
0 (0)
|
154 (3.3)
|
0.029
c
|
|
1-9
|
95 (74)
|
3703 (80)
| |
|
10-17
|
33 (26)
|
780 (17)
| |
|
WBC count (×10
9
/l)
| | | |
|
0-9
|
61 (48)
|
2408 (52)
|
0.51c
|
|
10-49
|
50 (39)
|
1453 (31)
| |
|
>50
|
17 (13)
|
776 (17)
| |
|
Platelet count (×10
9
/l)
d
| | | |
|
<50
|
76 (59)
|
2310 (50)
|
0.005
c
|
|
50-149
|
41 (32)
|
1473 (32)
| |
|
>150
|
6 (5)
|
755 (16)
| |
|
EMD
e
| | | |
|
CNS
|
5f (3.9)
|
125 (2.7)
|
NA
|
|
Mediastinal
|
4f (3.1)
|
72 (1.6)
| |
|
Testis
|
0 (0)
|
15 (0.6)
| |
- CNS, central nervous system; DS-ALL, Down syndrome-related acute lymphoblastic leukemia; EMD, extramedullary disease; NA, not analyzed due to lack of EMD data in several instances; WBC, white blood cell.
- aSignificant P values in bold type.
- bChi square test.
- cMann-Whitney U test.
- dData on platelet counts missing in 5 DS-ALL and in 99 non-DS-ALL patients.
- eData on CNS involvement missing in 16 non-DS-ALL patients, on mediastinal mass in one DS-ALL and in 51 non-DS-ALL patients, and on testicular involvement in 27 DS-ALL and in 990 non-DS-ALL patients.
- fOne patient had CNS involvement as well as a mediastinal mass.
