|
Features
|
DS-ALL (%)
|
non-DS-ALL (%)
|
P valuea
|
|---|
|
Karyotype
| | | |
|
Abnormal
|
57 (60)
|
2581 (79)
|
<0.0001
|
|
Normal
|
38 (40)
|
702 (21)
| |
|
Modal number
b
| | | |
|
Hypodiploidy
|
1 (1)
|
211 (6)
|
<0.0001
|
|
Pseudodiploidy
|
37 (39)
|
940 (29)
| |
|
Hyperdiploidy
|
17 (18)
|
329 (10)
| |
|
High hyperdiploidy
|
2 (2)
|
1075 (33)
| |
|
>67 chromosomes
|
0 (0)
|
26 (1)
| |
|
Normal karyotype
|
38 (40)
|
702 (21)
| |
|
TCF3
-
PBX1
c
| | | |
|
Yes
|
1 (2.6)
|
70 (4.2)
|
1.00
|
|
No
|
37 (97)
|
1592 (96)
| |
|
BCR
-
ABL1
c
| | | |
|
Yes
|
1 (2.1)
|
73 (3.7)
|
1.00
|
|
No
|
46 (98)
|
1923 (96)
| |
|
MLL
rearrangement
c
| | | |
|
Yes
|
0 (0)
|
122 (7.6)
|
0.07
|
|
No
|
41 (100)
|
1487 (92)
| |
|
ETV6
-
RUNX1
c
| | | |
|
Yes
|
8 (15)
|
568 (25)
|
0.11
|
|
No
|
46 (85)
|
1719 (75)
| |
|
t(8;14)(q11;q32)
| | | |
|
Yes
|
2 (2.1)
|
3 (0.09)
|
NA
|
|
No
|
93 (98)
|
3280 (99.9)
| |
|
iAMP21
d
| | | |
|
Yes
|
0 (0)
|
6 (1.1)
|
NA
|
|
No
|
12 (100)
|
558 (98.9)
| |
- DS-ALL, Down syndrome-related acute lymphoblastic leukemia; iAMP21, intrachromosomal amplification of chromosome 21; NA, not analyzed due to too few cases.
- aChi square test. Significant P values in bold type.
- bHypodiploidy was defined as <47 in DS and <46 in non-DS; pseudodiploidy as 47 in DS and 46 in non-DS; hyperdiploidy as 48–50 in DS and 47–50 in non-DS; and high hyperdiploidy as 51–67 chromosomes in both groups.
- cBased only on informative cases, i.e., on which targeted molecular genetic or FISH analyses of these rearrangements had been performed.
- dBased only on informative cases, i.e., on cases treated according to the ALL-2008 protocol and hence screened for iAMP21.
