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Table 2 Genetic features of the DS-ALL and the non-DS-ALL patients

From: Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries

Features DS-ALL (%) non-DS-ALL (%) P valuea
Karyotype    
 Abnormal 57 (60) 2581 (79) <0.0001
 Normal 38 (40) 702 (21)  
Modal number b    
 Hypodiploidy 1 (1) 211 (6) <0.0001
 Pseudodiploidy 37 (39) 940 (29)  
 Hyperdiploidy 17 (18) 329 (10)  
 High hyperdiploidy 2 (2) 1075 (33)  
 >67 chromosomes 0 (0) 26 (1)  
 Normal karyotype 38 (40) 702 (21)  
TCF3 - PBX1 c    
 Yes 1 (2.6) 70 (4.2) 1.00
 No 37 (97) 1592 (96)  
BCR - ABL1 c    
 Yes 1 (2.1) 73 (3.7) 1.00
 No 46 (98) 1923 (96)  
MLL rearrangement c    
 Yes 0 (0) 122 (7.6) 0.07
 No 41 (100) 1487 (92)  
ETV6 - RUNX1 c    
 Yes 8 (15) 568 (25) 0.11
 No 46 (85) 1719 (75)  
t(8;14)(q11;q32)    
 Yes 2 (2.1) 3 (0.09) NA
 No 93 (98) 3280 (99.9)  
iAMP21 d    
 Yes 0 (0) 6 (1.1) NA
 No 12 (100) 558 (98.9)  
  1. DS-ALL, Down syndrome-related acute lymphoblastic leukemia; iAMP21, intrachromosomal amplification of chromosome 21; NA, not analyzed due to too few cases.
  2. aChi square test. Significant P values in bold type.
  3. bHypodiploidy was defined as <47 in DS and <46 in non-DS; pseudodiploidy as 47 in DS and 46 in non-DS; hyperdiploidy as 48–50 in DS and 47–50 in non-DS; and high hyperdiploidy as 51–67 chromosomes in both groups.
  4. cBased only on informative cases, i.e., on which targeted molecular genetic or FISH analyses of these rearrangements had been performed.
  5. dBased only on informative cases, i.e., on cases treated according to the ALL-2008 protocol and hence screened for iAMP21.