Clinical and genetic features of pediatric acute lymphoblastic leukemia in Down syndrome in the Nordic countries

Table 3 Survival of the DS-ALL patients treated according to the ALL-1992/2000 protocols in relation to clinical and genetic features

Features	5-year EFS (SE)	P value^a	5-year OS (SE)	P value^a
Gender
Female	0.619 (0.080)	0.46	0.693 (0.078)	0.50
Male	0.534 (0.080)		0.621 (0.081)
Age (years)
0-4	0.479 (0.106)	0.88	0.632 (0.091)	0.77
≥5	0.558 (0.076)		0.668 (0.073)
WBC count (×10 ⁹ /l)
0-9	0.574 (0.086)	0.78	0.752 (0.076)	0.36
≥10	0.574 (0.077)		0.644 (0.074)
0-49	0.610 (0.061)	0.026	0.747 (0.055)	0.003
≥50	0.364 (0.145)		0.364 (0.145)
Karyotype
Abnormal	0.558 (0.076)	0.86	0.668 (0.073)	0.92
Normal	0.468 (0.116)		0.661 (0.107)

DS-ALL, Down syndrome-related acute lymphoblastic leukemia; EFS, event-free survival; OS, overall survival; SE, standard error; WBC, white blood cell.
^aSignificant P values in bold type.

ISSN: 1756-8722