Figure 1

Primary structures of mRNAs encoded by wild-type and 3′UTR-variant ζ-globin mRNAs. Native and mutated regions of each 3′UTR sequence are denoted in uppercase and lowercase bold, respectively. The UGA termination codon and AAUAAA polyadenylation signal are boxed; the polyadenylate tail is indicated as (A_n). The tetranucleotide motif that confers stability to the ζWT mRNA is highlighted in gray.